|Related Categories||Cell Biology, Cell Signaling and Neuroscience, Natriuretic Peptides, Neuropeptides, Peptides and Proteins,|
|composition||Peptide content, ≥65%|
|Gene Information||human ... NPPC(4880)|
C-type natriuretic peptide is produced in the hypothalamus, anterior pituitary, and most major endocrine glands. It has potent venodilatory and coronary vasodilatory effects, but minimal effects on renal function.
Renin-angiotensin blockade combined with natriuretic peptide system augmentation: novel therapeutic concepts to combat heart failure. von Lueder TG, Sangaralingham SJ, Wang BH, et al. Circ. Heart Fail. 6(3), 594-605, (2013)
C2238 atrial natriuretic peptide molecular variant is associated with endothelial damage and dysfunction through natriuretic peptide receptor C signaling. Sciarretta S, Marchitti S, Bianchi F, et al. Circ. Res. 112(10), 1355-64, (2013)
[109th Scientific Meeting of the Japanese Society of Internal Medicine: symposium: 2. Translational research and evidence-based medicine (EBM) in internal medicine in Japan, translational research; 4) Translational research of endocrinology and metabolism]. Hosoda K, Yasoda A, Ebihara K, et al. Nippon. Naika Gakkai Zasshi. 101(9), 2552-62, (2012)
[The balance of markers of regulation vascular tone and fibrinogen in the prognosis of hemorrhagic transformation and fatal outcome in the acute period of ischemic stroke]. Liang OV, Kochetov AG, Arkhipkin AA, et al. Klin. Med. (Mosk.) 90(8), 55-60, (2012)
C-type natriuretic peptide protects the retinal pigment epithelium against advanced glycation end product-induced barrier dysfunction. Dahrouj M, Alsarraf O, Liu Y, et al. J. Pharmacol. Exp. Ther. 344(1), 96-102, (2013)
Overexpressed C-type natriuretic peptide serves as an early compensatory response to counteract extracellular matrix remodeling in unilateral ureteral obstruction rats. Hu P, Wang J, Zhao XQ, et al. Mol. Biol. Rep. 40(2), 1429-41, (2013)
Physiological levels of A-, B- and C-type natriuretic peptide shed the endothelial glycocalyx and enhance vascular permeability. Jacob M, Saller T, Chappell D, et al. Basic Res. Cardiol. 108(3), 347, (2013)
Trypanosoma cruzi infection and endothelin-1 cooperatively activate pathogenic inflammatory pathways in cardiomyocytes. Corral RS, Guerrero NA, Cuervo H, et al. PLoS Negl. Trop. Dis. 7(2), e2034, (2013)
Intracerebroventricular administration of C-type natriuretic peptide suppresses food intake via activation of the melanocortin system in mice. Yamada-Goto N, Katsuura G, Ebihara K, et al. Diabetes 62(5), 1500-4, (2013)
Caloric restriction, but not caloric loading, affects circulating fetal and maternal C-type natriuretic peptide concentrations in late ovine gestation. McNeill BA, Barrell GK, Ridgway MJ, et al. Reprod. Fertil. Dev. 24(8), 1063-70, (2012)
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