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  • O0382 - Anti-Opioid δ Receptor antibody produced in rabbit

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O0382 Sigma

Anti-Opioid δ Receptor antibody produced in rabbit

whole antiserum, lyophilized powder

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Neurotransmission, Antibodies to Neurotransmitter Receptors, Neuroscience,
species reactivity   mouse (predicted), rat
application(s)   immunocytochemistry: 1:800 using PLP fixed rat brain sections
  western blot: 1:800 using whole brain homogenate
clone   polyclonal
antibody form   whole antiserum
form   lyophilized powder
mol wt   antigen mol wt ~55 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   mouse ... Oprd1(18386)
rat ... Oprd1(24613)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

Peptide corresponding to the carboxy-terminal of the opioid δ receptor covalently attached onto a carrier protein.

General description

Opioid peptides are endogenous neuromodulators that play a major role in nociception by interacting with several membrane receptors. Molecular cloning techniques have characterized the nucleotide sequence of several distinct opioid receptors, including the δ-, κ- and μ-opioid receptors.1 The cloned receptors are highly homologous (65%), differing only at the N- and C-termini and at the extracelluar loops that confer binding specificity.2 All three receptors interact with heterotrimeric G proteins.3
δ-Opioid receptors (DOR) are located postsynaptically on pallidostriatal feedback neurons.4 DORs also modulate nociception presynaptically in the periaqueductal gray where immunolabeling of DOR has been shown to be intracellular and often associated with large dense-core vesicles. 5 Additionally, receptor autoradiographic investigations have localized DORs to the external plexiform layer of the olfactory bulb, the nucleus accumbens, several layers of the cerebral cortex and several nuclei of the amygdala.6

References
1. Goldstein, A. Trends Pharmacol. Sci., 8, 456-459 (1987).
2. Reisine, T., Bell, G.I. Trends Neurosci., 16, 506-510 (1993).
3. Childers, S.R. Life Sci., 48, 1991-2003 (1991).
4. Olive, M.F. et al. J. Neurosci., 17, 7471-7479 (1997).
5. Commons, K.G. et al. J. Comp. Neurol., 430, 200-208 (2001).
6. Quock, R.M. et al. Pharmacol. Rev., 51, 503-532 (1999).

Specificity

The antiserum is specific for the COOH terminal of the opioid δ receptor.

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