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O0391 Sigma

Olopatadine hydrochloride

≥98% (HPLC)

Synonym: (11Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride, AL-4943A, KW-4679, Opatanol, Patanol

  • CAS Number 140462-76-6

  • Empirical Formula (Hill Notation) C21H23NO3·HCl

  • Molecular Weight 373.87

  •  MDL number MFCD00875716

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, O
assay   ≥98% (HPLC)
form   solid
solubility   H2O: ≥20 mg/mL
storage temp.   room temp

Description

Biochem/physiol Actions

Olopatadine is a histamine H1 receptor antagonist and mast cell stabilizer. The low level of occupancy H1 receptors in the brain explains the low sedation effect of olopatidine. It is believed that olopatidine is a substrate for P-glycoprotein, which limits its brain penetration.

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UN 2811 6.1 / PGIII
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