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  • O0884 - Monoclonal Anti-Oncostatin M antibody produced in mouse

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O0884 Sigma

Monoclonal Anti-Oncostatin M antibody produced in mouse

clone 17001, purified immunoglobulin, lyophilized powder

Synonym: Anti-OSM

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cytokines and Growth Factors, Antibodies to Oncostatin M (OSM),
species reactivity   human
application(s)   indirect ELISA: suitable
  neutralization: suitable
  western blot: suitable
clone   17001, monoclonal
antibody form   purified immunoglobulin
form   lyophilized powder
isotype   IgG2a
storage temp.   −20°C
Gene Information   human ... OSM(5008)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

recombinant human OSM expressed in Escherichia coli.

General description

Oncostatin M (OSM) is a growth-regulating cytokine produced by the activated T lymphocytes and macrophages. It has a pivotal role in stimulating the production of IL-6 in cultured human endothelial cells. It also facilitates the LDL receptor expression and its uptake by hepatoma cells. Further, OSM can induce synovial fibroblast-like cells to produce urokinase type plasminogen activator. Monoclonal anti-Oncostatin M antibody can be used for neutralizing the biological activity of rhOSM on the human TF-1 cell line. Mouse anti-Oncostatin M antibody reacts specifically with recombinant human OSM. The product has shown no cross-reactivity with recombinant human IL-6, IL-11, CNTF, LIF and recombinant mouse OSM.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline (PBS) with 5% trehalose.

Specificity

The antibody neutralizes the biological activity of recombinant human OSM. Does not cross-react with recombinant human IL-6, IL-11, CNTF, LIF and recombinant mouse OSM.

Preparation Note

Purified using protein A.

Application

Monoclonal anti-Oncostatin M antibody can be used in western blotting and capture ELISA.

Price and Availability


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Safety & Documentation

Documents

Certificate of Analysis

Certificate of Origin

Safety Information

Personal Protective Equipment  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  NONH for all modes of transport
WGK Germany  2
Protocols & Articles

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Peer-Reviewed Papers
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References

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