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O0884 Sigma

Monoclonal Anti-Oncostatin M antibody produced in mouse

clone 17001, purified immunoglobulin, lyophilized powder

Synonym: Anti-OSM

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cytokines and Growth Factors, Antibodies to Oncostatin M (OSM),
species reactivity   human
application(s)   indirect ELISA: suitable
  neutralization: suitable
  western blot: suitable
clone   17001, monoclonal
antibody form   purified immunoglobulin
form   lyophilized powder
isotype   IgG2a
storage temp.   −20°C
Gene Information   human ... OSM(5008)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

recombinant human OSM expressed in Escherichia coli.

General description

Oncostatin M (OSM) is a growth-regulating cytokine produced by the activated T lymphocytes and macrophages. It has a pivotal role in stimulating the production of IL-6 in cultured human endothelial cells. It also facilitates the LDL receptor expression and its uptake by hepatoma cells. Further, OSM can induce synovial fibroblast-like cells to produce urokinase type plasminogen activator. Monoclonal anti-Oncostatin M antibody can be used for neutralizing the biological activity of rhOSM on the human TF-1 cell line. Mouse anti-Oncostatin M antibody reacts specifically with recombinant human OSM. The product has shown no cross-reactivity with recombinant human IL-6, IL-11, CNTF, LIF and recombinant mouse OSM.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline (PBS) with 5% trehalose.

Specificity

The antibody neutralizes the biological activity of recombinant human OSM. Does not cross-react with recombinant human IL-6, IL-11, CNTF, LIF and recombinant mouse OSM.

Preparation Note

Purified using protein A.

Application

Monoclonal anti-Oncostatin M antibody can be used in western blotting and capture ELISA.

Price and Availability


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