|Related Categories||Antibiotics, Antibiotics A to Z, Antibiotics N-S, Bioactive Small Molecules, Cell Biology,|
|biological source||from Petromyces albertensis|
Ochratoxin A is a mycotoxin found in food that is nephrotoxic and carcinogenic in the kidney and induces differentiation in cloned renal cell lines. Increases endoplasmic reticulum ATP-dependent Ca2+ pump activity.
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from Aspergillus flavus
reference material, from Aspergillus ochraceus
10 μg/mL in acetonitrile, analytical standard, for environmental analysis
50 μg/mL in benzene: acetic acid (99:1), analytical standard
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P264-P281-P301 + P310|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T+|
|Risk Statements (Europe)||28-40|
|Safety Statements (Europe)||28-36/37-45|
|RIDADR||UN 3462 6.1/PG 2|
Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
BioFiles 2007, 2.4, 20.
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Environmental, Gene expression, Metabolites, Methylations, Mutagens, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription
Ochratoxin A-induced stimulation of extracellular signal-regulated kinases 1/2 is associated with Madin-Darby canine kidney-C7 cell dedifferentiation. Schramek, H., et al. J. Pharmacol. Exp. Ther. 283, 1460-1468, (1997)
Alterations in ATP-dependent calcium uptake by rat renal cortex microsomes following ochratoxin A administration in vivo or addition in vitro. Chong, X., and Rahimtula, A.D. Biochem. Pharmacol. 44, 1401-1409, (1992)
Low Doses Of Ochratoxin A Upregulate The Protein Expression Of Organic Anion Transporters Oat1, Oat2, Oat3 And Oat5 In Rat Kidney Cortex. Zlender, V., et al. Toxicol. Appl. Pharmacol. 239, 284-96, (2009)
Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. Gregory Kaler et al J. Biol. Chem. 282, 23841-53, (2007)
Susceptibility and mode of binding of the Mycobacterium tuberculosis cysteinyl transferase mycothiol ligase to tRNA synthetase inhibitors. Maria-Teresa Gutierrez-Lugo et al Bioorg. Med. Chem. Lett. 21, 2480-3, (2011)
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