EMAIL THIS PAGE TO A FRIEND

O1877 Sigma

Ochratoxin A

from Petromyces albertensis, ≥98% (HPLC)

Synonym: N-[(3R)-(5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-L-phenylalanine

Purchase

Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
Quality Level   PREMIUM
biological source   from Petromyces albertensis
assay   ≥98% (HPLC)
form   powder
impurities   Benzene, free
solubility   ethanol: soluble
storage temp.   2-8°C

Description

Biochem/physiol Actions

Ochratoxin A is a mycotoxin found in food that is nephrotoxic and carcinogenic in the kidney and induces differentiation in cloned renal cell lines. Increases endoplasmic reticulum ATP-dependent Ca2+ pump activity.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




Duolink Webinar

Customers Also Viewed

Ochratoxin A

from Aspergillus ochraceus, reference material

Ochratoxin A solution

10 μg/mL in acetonitrile, analytical standard

Zearalenone

fungal mycotoxin

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Hazard Codes (Europe) 
T+
Risk Statements (Europe) 
Safety Statements (Europe) 
28-36/37-45
RIDADR 
UN 3462 6.1 / PGII
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

DNA Damage and Repair

Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
BioFiles 2007, 2.4, 20.
Keywords: AGE, Alkylations, Apoptosis, Applications, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Environmental, Error, Events, Gene expression, Metabolites, Methylations, Mutagens, Oxidations, Polymorphisms, Rearrangements, Recombination, Sequences, Substitutions, Transcription, Type

Related Content

Carcinogen Selector - Digestive System - Liver

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Digestive System - Liver
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Endocrine System - Liver Endocrine

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Endocrine System - Liver Endocrine
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Endocrine System - Mammary Gland

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Endocrine System - Mammary Gland
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Endocrine System

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Endocrine System
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Urinary System - Kidney

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Urinary System - Kidney
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Urinary System

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Urinary System
Keywords: Cancer, Carcinogens, Respiratory

Peer-Reviewed Papers

References

Set your institution to view full text papers.

Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. Gregory Kaler et al J. Biol. Chem. 282, 23841-53, (2007)

Loading...


A review on ochratoxin A transcriptomic studies. Vettorazzi A, van Delft J, and López de Cerain A Food Chem. Toxicol. 59, 766-83, (2013)

Loading...


Peritubular transport of ochratoxin A by single rabbit renal proximal tubules. Welborn, J.R., et al. J. Am. Soc. Nephrol. 9, 1973-1982, (1998)

Loading...


Ochratoxin a and mitotic disruption: mode of action analysis of renal tumor formation by ochratoxin A. Mally A Toxicol. Sci. 127(2), 315-30, (2012)

Loading...


Endocrine disrupting effects of ochratoxin A at the level of nuclear receptor activation and steroidogenesis. Frizzell C, Verhaegen S, Ropstad E, et al. Toxicol. Lett. 217(3), 243-50, (2013)

Loading...


Ochratoxin A secretion in primary cultures of rabbit renal proximal tubule cells. Groves, C.E., et al. J. Am. Soc. Nephrol. 10, 13-20, (1999)

Loading...


Effect of superoxide dismutase and catalase on the nephrotoxicity induced by subchronical administration of ochratoxin A in rats. Baudrimont, I., et al. Toxicology 89, 101-111, (1994)

Loading...


Relationship between ecophysiological factors, growth and ochratoxin A contamination of dry-cured sausage based matrices. Rodríguez A, Capela D, Medina Á, et al. Int. J. Food Microbiol. 194, 71-7, (2015)

Loading...


Oxidative stress induces the biosynthesis of citrinin by Penicillium verrucosum at the expense of ochratoxin. Schmidt-Heydt M, Stoll D, Schütz P, et al. Int. J. Food Microbiol. 192, 1-6, (2015)

Loading...


Biocontrol activity of four non- and low-fermenting yeast strains against Aspergillus carbonarius and their ability to remove ochratoxin A from grape juice. Fiori S, Urgeghe PP, Hammami W, et al. Int. J. Food Microbiol. 189, 45-50, (2014)

Loading...


The impact of water and temperature interactions on lag phase, growth and potential ochratoxin A production by two new species, Aspergillus aculeatinus and A. sclerotiicarbonarius, on a green coffee-based medium. Akbar A and Magan N Int. J. Food Microbiol. 188, 116-21, (2014)

Loading...


Role of microRNA-29b in the ochratoxin A-induced enhanced collagen formation in human kidney cells. Hennemeier I, Humpf HU, Gekle M, et al. Toxicology 324, 116-22, (2014)

Loading...


Biodegradation of ochratoxin A by Pediococcus parvulus isolated from Douro wines. Abrunhosa L, Inês A, Rodrigues AI, et al. Int. J. Food Microbiol. 188, 45-52, (2014)

Loading...


QuickTox Kit for QuickScan Ochratoxin-A. Davis AH, Roberts RW, and Ziemer W J. AOAC Int. 96(5), 1019-25, (2013)

Loading...


A review of the diagnosis and treatment of Ochratoxin A inhalational exposure associated with human illness and kidney disease including focal segmental glomerulosclerosis. Hope JH and Hope BE J. Environ. Public Health 2012, 835059, (2012)

Loading...


Ecophysiology of Aspergillus section nigri species potential ochratoxin a producers. Astoreca AL, Magnoli CE, and Dalcero AM Toxins (Basel.) 2(11), 2593-605, (2010)

Loading...


Mechanism of action of ochratoxin A. Dirheimer, G., and Creppy, E.E. IARC Sci. Publ. 115, 171-186, (1991)

Loading...


Ochratoxin A in feed of food-producing animals: an undesirable mycotoxin with health and performance effects. Duarte SC, Lino CM, and Pena A Vet. Microbiol. 154(1-2), 1-13, (2011)

Loading...


Design of PEG-aptamer two piece macromolecules as convenient and integrated sensing platform: application to the label free detection of small size molecules. Hayat A, Andreescu S, and Marty JL Biosens. Bioelectron. 45, 168-73, (2013)

Loading...


Femtogram ultrasensitive aptasensor for the detection of Ochratoxin A. Ma W, Yin H, Xu L, et al. Biosens. Bioelectron. 42, 545-9, (2013)

Loading...


A reassessment of risk associated with dietary intake of ochratoxin A based on a lifetime exposure model. Haighton LA, Lynch BS, Magnuson BA, et al. Crit. Rev. Toxicol. 42(2), 147-68, (2012)

Loading...


Food safety implications of ochratoxin A in animal-derived food products. Duarte SC, Lino CM, and Pena A Vet. J. 192(3), 286-92, (2012)

Loading...


Metabolic pathways of ochratoxin A. Wu Q, Dohnal V, Huang L, et al. Curr. Drug Metab. 12(1), 1-10, (2011)

Loading...


Highly sensitive ochratoxin A impedimetric aptasensor based on the immobilization of azido-aptamer onto electrografted binary film via click chemistry. Hayat A, Sassolas A, Marty JL, et al. Talanta 103, 14-9, (2013)

Loading...


An update on direct genotoxicity as a molecular mechanism of ochratoxin a carcinogenicity. Pfohl-Leszkowicz A and Manderville RA Chem. Res. Toxicol. 25(2), 252-62, (2012)

Loading...


Determination of aflatoxins, deoxynivalenol, ochratoxin A and zearalenone in wheat and oat based bran supplements sold in the Spanish market. Vidal A, Marín S, Ramos AJ, et al. Food Chem. Toxicol. 53, 133-8, (2013)

Loading...


Screening interaction between ochratoxin A and aptamers by fluorescence anisotropy approach. Geng X, Zhang D, Wang H, et al. Anal. Bioanal. Chem 405(8), 2443-9, (2013)

Loading...


Simultaneous determination of aflatoxin B(1) and ochratoxin A in licorice roots and fritillary bulbs by solid-phase extraction coupled with high-performance liquid chromatography-tandem mass spectrometry. Wang L, Wang Z, Gao W, et al. Food Chem. 138(2-3), 1048-54, (2013)

Loading...


Functional characterization of the polyketide synthase gene required for ochratoxin A biosynthesis in Penicillium verrucosum. Abbas A, Coghlan A, O'Callaghan J, et al. Int. J. Food Microbiol. 161(3), 172-81, (2013)

Loading...


An aptasensing platform for simultaneous detection of multiple analytes based on the amplification of exonuclease-catalyzed target recycling and DNA concatemers. Jiang L, Peng J, Yuan R, et al. Analyst 138(17), 4818-22, (2013)

Loading...


Comparative proteomics and physiological characterization of Arabidopsis thaliana seedlings in responses to Ochratoxin A. Wang Y, Hao J, Zhao W, et al. Plant Mol. Biol. 82(4-5), 321-37, (2013)

Loading...


Characterization of an ochratoxin-A-dedifferentiated and cloned renal epithelial cell line. Gekle, M., et al. Toxicol. Appl. Pharmacol. 152, 282-291, (1998)

Loading...


First evidence of placental transfer of ochratoxin A in horses. Minervini F, Giannoccaro A, Nicassio M, et al. Toxins (Basel.) 5(1), 84-92, (2013)

Loading...


Low Doses Of Ochratoxin A Upregulate The Protein Expression Of Organic Anion Transporters Oat1, Oat2, Oat3 And Oat5 In Rat Kidney Cortex. Zlender, V., et al. Toxicol. Appl. Pharmacol. 239, 284-96, (2009)

Loading...


Total synthesis and cytotoxicity evaluation of all ochratoxin A stereoisomers. Benedikt Cramer et al Bioorg. Med. Chem. 18, 343-7, (2010)

Loading...


Combinatorial approach of LC-MS/MS and LC-TOF-MS for uncovering in vivo kinetics and biotransformation of ochratoxin A in rat. Han Z, Zhao Z, Shi J, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 925, 46-53, (2013)

Loading...


Multiplex real-time PCR method for detection and quantification of mycotoxigenic fungi belonging to three different genera. Vegi A and Wolf-Hall CE J. Food Sci. 78(1), M70-6, (2013)

Loading...


Sex- and strain-specific expression of cytochrome P450s in ochratoxin A-induced genotoxicity and carcinogenicity in rats. Pfohl-Leszkowicz, A., et al. Mol. Carcinog. 23, 76-85, (1998)

Loading...


Producers and important dietary sources of ochratoxin A and citrinin. Ostry V, Malir F, and Ruprich J Toxins (Basel.) 5(9), 1574-86, (2013)

Loading...


Sampling of cereals and cereal-based foods for the determination of ochratoxin A: an overview. Tittlemier SA, Varga E, Scott PM, et al. Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 28(6), 775-85, (2011)

Loading...


Immunochemical methods for ochratoxin A detection: a review. Meulenberg EP Toxins (Basel.) 4(4), 244-66, (2012)

Loading...


Ochratoxin A-induced stimulation of extracellular signal-regulated kinases 1/2 is associated with Madin-Darby canine kidney-C7 cell dedifferentiation. Schramek, H., et al. J. Pharmacol. Exp. Ther. 283, 1460-1468, (1997)

Loading...


Microfluidic channel with embedded SERS 2D platform for the aptamer detection of ochratoxin A. Galarreta BC, Tabatabaei M, Guieu V, et al. Anal. Bioanal. Chem 405(5), 1613-21, (2013)

Loading...


Molecular mechanisms underlying ochratoxin A-induced genotoxicity: global gene expression analysis suggests induction of DNA double-strand breaks and cell cycle progression. Hibi D, Kijima A, Kuroda K, et al. J. Toxicol. Sci. 38(1), 57-69, (2013)

Loading...


Wavelength-dependent degradation of ochratoxin and citrinin by light in vitro and in vivo and its implications on Penicillium. Schmidt-Heydt M, Cramer B, Graf I, et al. Toxins (Basel.) 4(12), 1535-51, (2012)

Loading...


Review. Ochratoxin A: presence in human plasma and intake estimation. Coronel MB, Sanchis V, Ramos AJ, et al. Food Sci. Technol. Int. 16(1), 5-18, (2010)

Loading...


The effects of different ecophysiological factors on ochratoxin A production. Khalesi M and Khatib N Environ. Toxicol. Pharmacol. 32(2), 113-21, (2011)

Loading...


Susceptibility and mode of binding of the Mycobacterium tuberculosis cysteinyl transferase mycothiol ligase to tRNA synthetase inhibitors. Maria-Teresa Gutierrez-Lugo et al Bioorg. Med. Chem. Lett. 21, 2480-3, (2011)

Loading...


Multi-component immunochromatographic assay for simultaneous detection of aflatoxin B1, ochratoxin A and zearalenone in agro-food. Li X, Li P, Zhang Q, et al. Biosens. Bioelectron. 49, 426-32, (2013)

Loading...


Label-free homogeneous FRET immunoassay for the detection of mycotoxins that utilizes quenching of the intrinsic fluorescence of antibodies. Li T, Byun JY, Kim BB, et al. Biosens. Bioelectron. 42, 403-8, (2013)

Loading...


Novel IAC-LC-ESI-MS(2) analytical set-up for ochratoxin A determination in pork. Duarte SC, Lino CM, and Pena A Food Chem. 138(2-3), 1055-61, (2013)

Loading...


VeA and LaeA transcriptional factors regulate ochratoxin A biosynthesis in Aspergillus carbonarius. Crespo-Sempere A, Marín S, Sanchis V, et al. Int. J. Food Microbiol. 166(3), 479-86, (2013)

Loading...


Identification and quantification of fungi and mycotoxins from Pu-erh tea. Haas D, Pfeifer B, Reiterich C, et al. Int. J. Food Microbiol. 166(2), 316-22, (2013)

Loading...


In vitro study on the effect of Saccharomyces cerevisiae strains on growth and mycotoxin production by Aspergillus carbonarius and Fusarium graminearum. Armando MR, Dogi CA, Poloni V, et al. Int. J. Food Microbiol. 161(3), 182-8, (2013)

Loading...


Apoptosis induction by OTA and TNF-α in cultured primary rat hepatocytes and prevention by silibinin. Essid E, Dernawi Y, and Petzinger E Toxins (Basel.) 4(11), 1139-56, (2012)

Loading...


Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta mice. Hibi D, Kijima A, Suzuki Y, et al. Toxicology 304, 92-9, (2013)

Loading...


Zinc protects HepG2 cells against the oxidative damage and DNA damage induced by ochratoxin A. Zheng J, Zhang Y, Xu W, et al. Toxicol. Appl. Pharmacol. 268(2), 123-31, (2013)

Loading...


Effect of Robusta (Coffea canephora P.) coffee cherries quantity put out for sun drying on contamination by fungi and ochratoxin A (OTA) under tropical humid zone (Côte d'Ivoire). Kouadio IA, Koffi LB, Nemlin JG, et al. Food Chem. Toxicol. 50(6), 1969-79, (2012)

Loading...


Simultaneous determination of bisphenol A, aflatoxin B1, ochratoxin A, and patulin in food matrices by liquid chromatography/mass spectrometry. Song W, Li C, and Moezzi B Rapid Commun. Mass Spectrom. 27(6), 671-80, (2013)

Loading...


Effects of ochratoxin A on DNA repair in cultures of rat hepatocytes and porcine urinary bladder epithelial cells. Dorrenhaus, A., and Follmann, W. Arch. Toxicol. 71, 709-713, (1997)

Loading...


Aptamers: a promosing tool for ochratoxin A detection in food analysis. Rhouati A, Yang C, Hayat A, et al. Toxins (Basel.) 5(11), 1988-2008, (2013)

Loading...


Deleterious effects of mycotoxin combinations involving ochratoxin A. Klarić MS, Rašić D, and Peraica M Toxins (Basel.) 5(11), 1965-87, (2013)

Loading...


Ochratoxin A management in vineyards by Lobesia botrana biocontrol. Cozzi G, Somma S, Haidukowski M, et al. Toxins (Basel.) 5(1), 49-59, (2013)

Loading...


Occurrence of Ochratoxin A in the wild boar (Sus scrofa): chemical and histological analysis. Bozzo G, Ceci E, Bonerba E, et al. Toxins (Basel.) 4(12), 1440-50, (2012)

Loading...


Development of nanogold-based lateral flow immunoassay for the detection of ochratoxin A in buffer systems. Moon J, Kim G, and Lee S J. Nanosci. Nanotechnol. 13(11), 7245-9, (2013)

Loading...


Distribution and mycotoxigenic potential of Aspergillus section Nigri species in naturally contaminated almonds. Palumbo JD and O'Keeffe TL J. Food Prot. 76(4), 702-6, (2013)

Loading...


Control of ochratoxin A production in grapes. Ponsone ML, Chiotta ML, Palazzini JM, et al. Toxins (Basel.) 4(5), 364-72, (2012)

Loading...


Determination of ochratoxin A in licorice and licorice extracts by high-performance liquid chromatography coupled with fluorescence detection: collaborative study. Lerda D, Ambrosio M, Kunsagi Z, et al. J. AOAC Int. 96(2), 331-40, (2013)

Loading...


Protective effect of lycopene against ochratoxin A induced renal oxidative stress and apoptosis in rats. Palabiyik SS, Erkekoglu P, Zeybek ND, et al. Exp. Toxicol. Pathol. 65(6), 853-61, (2013)

Loading...


[Ochratoxin A in foods for human consumption: review]. Ravelo Abreu A, Rubio Armendáriz C, Gutiérrez Fernández AJ, et al. Nutr. Hosp. 26(6), 1215-26, (2011)

Loading...


Induction of free radicals in hepatocytes, mitochondria and microsomes of rats by ochratoxin A and its analogs. Hoehler, D., et al. Biochim. Biophys. Acta 1357, 225-233, (1997)

Loading...


Alterations in ATP-dependent calcium uptake by rat renal cortex microsomes following ochratoxin A administration in vivo or addition in vitro. Chong, X., and Rahimtula, A.D. Biochem. Pharmacol. 44, 1401-1409, (1992)

Loading...


The loss of the inducible Aspergillus carbonarius MFS transporter MfsA leads to ochratoxin A overproduction. Crespo-Sempere A, Martínez-Culebras PV, and González-Candelas L Int. J. Food Microbiol. 181, 1-9, (2014)

Loading...


Development of a stir bar sorptive extraction method for analysis of ochratoxin A in beer. Nguyen KT and Ryu D J. AOAC Int. 97(4), 1092-6, (2014)

Loading...


Identification and characterization of the polyketide synthase involved in ochratoxin A biosynthesis in Aspergillus carbonarius. Gallo A, Knox BP, Bruno KS, et al. Int. J. Food Microbiol. 179, 10-7, (2014)

Loading...


The influence of salt (NaCl) on ochratoxin A biosynthetic genes, growth and ochratoxin A production by three strains of Penicillium nordicum on a dry-cured ham-based medium. Rodríguez A, Medina Á, Córdoba JJ, et al. Int. J. Food Microbiol. 178, 113-9, (2014)

Loading...


Downregulation of Rad51 participates in OTA-induced DNA double-strand breaks in GES-1 cells in vitro. Lian H, Cui J, Wang Y, et al. Toxicol. Lett. 226(2), 214-21, (2014)

Loading...


Quercetin modulates OTA-induced oxidative stress and redox signalling in HepG2 cells - up regulation of Nrf2 expression and down regulation of NF-κB and COX-2. Ramyaa P, Krishnaswamy R, and Padma VV Biochim. Biophys. Acta 1840(1), 681-92, (2014)

Loading...


Toxicity of ochratoxin a and its modulation by antioxidants: a review. Sorrenti V, Di Giacomo C, Acquaviva R, et al. Toxins (Basel.) 5(10), 1742-66, (2013)

Loading...


Ochratoxin A induces karyomegaly and cell cycle aberrations in renal tubular cells without relation to induction of oxidative stress responses in rats. Taniai E, Yafune A, Nakajima M, et al. Toxicol. Lett. 224(1), 64-72, (2014)

Loading...


Merck 14,6740

Beil. 18,V,9,56

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?