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O3125 Sigma

Ouabain octahydrate

≥95% (HPLC), powder

Synonym: 1β,3β,5β,11α,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside), Acocantherine, G-Strophanthin

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Properties

Related Categories A to C, Adenosinetriphosphatase, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents,
InChI Key   TYBARJRCFHUHSN-DMJRSANLSA-N
assay   ≥95% (HPLC)
form   powder
optical activity   [α]25/D −31 to −32.5° in H2O(lit.)
impurities   ~8 mol/mol water
color   white
solubility   H2O: soluble10 mg/mL (cold)
  ethanol: soluble10 mg/mL
  H2O: soluble50 mg/mL (hot)
absorption   ε1mM/220 nm, H2O 15.5
Gene Information   human ... ATIC(471)
rat ... Atp1b1(25650)

Description

Caution

Aqueous solutions can be autoclaved.

Biochem/physiol Actions

Cardiac glycoside, inhibits Na(+)/K(+) ATPase, regulates transcription of MDR (increase, Pgp) and MRP (increase MRP1 and decrease CFTR, cyctic fibrosis transport receptor or cAMP-activated Cl- channel) genes, also alters localization of MRP1. Ouabain resistance is associated with appearance of Na(+)/K(+) ATPase isoforms with low binding affinity.

Features and Benefits

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Legal Information

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Biomedical Applications
Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 1544PSN1 6.1 / PGI
WGK Germany 
3
Protocols & Articles

Articles

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Keywords: Absorption, Bioactive small molecules, Clinical, Metabolism

Discover Bioactive Small Molecules for Ion Channels Research

Ion transport across the relatively impermeable lipid bilayer of the cell membrane is accomplished via membrane proteins known as ion channels, pumps and transporters. Ion channels are gated pores an...
Keywords: Biological processes, Cell signaling, Diseases, Hormones, Ligands, Neurotransmitters

Peer-Reviewed Papers
15

References

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