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O3251 Sigma

Oxytocin

Synonym: α-Hypophamine, Oxytocic hormone

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Oxytocin,
InChI Key   XNOPRXBHLZRZKH-DSZYJQQASA-N
assay   ≥97% (HPLC)
form   lyophilized powder
storage temp.   2-8°C
Gene Information   human ... OXT(5020), OXTR(5021)
rat ... Oxtr(25342)

Description

Amino Acid Sequence

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 [Disulfide Bridge: 1-6]

Biochem/physiol Actions

Stimulates uterine contraction and lactation; increases Na+ excretion; stimulates myometrial GTPase and phospholipase C.

Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation. OXT has been implicated in hydromineral homeostasis and vascular and cardiac relaxation. Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders and autism. OXT has a potential as a marker of autism severity. OXT is an anorexigenic neuropeptide, which is implicated in social cognition and obsessive-compulsive behavior. Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings. Deficiency of OXT hormone might contribute to pathogenesis of attention deficit/hyperactivity disorder (ADHD).

Packaging

500, 1000, 5000 I.U. in glass bottle

Physical form

Supplied as a powder with a peptide content of ≥ 75%

Application

Oxytocin has been used in experimental study to induce uterine contractions in rats. It has been used in comet assay to determine the number of cells with DNA damage.

General description

Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13. It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. OXT gene consists of three exons and two introns where first exon codes for hormone OXT while other exon codes for neurophysin I.

Price and Availability


Amplified Detection

All labs need water

Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

HPLC Analysis of Peptides on Discovery® BIO Wide Pore C18 (Gradient #2)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Peptides on Discovery® BIO Wide Pore C18 (Gradient #2)
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Peptides on Discovery® BIO Wide Pore C5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Peptides on Discovery® BIO Wide Pore C5
Keywords: Chromatography, High performance liquid chromatography

LC/MS Analysis of Polypeptide Drugs on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Polypeptide Drugs on Ascentis® Express RP-Amide
Keywords: Chromatography, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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