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O3636 Sigma

1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

powder

Synonym: ODQ

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, D to K,
InChI Key   LZMHWZHOZLVYDL-UHFFFAOYSA-N
form   powder
color   pale yellow
solubility   ethanol: soluble1.2 mg/mL
  DMSO: soluble5 mg/mL
  H2O: insoluble
storage temp.   2-8°C
Gene Information   human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

Description

Biochem/physiol Actions

Selective inhibitor of nitric oxide-sensitive guanylyl cyclase.

H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) non competitively inhibits the action of nitric oxide-sensitive guanylyl cyclase and results in a supposedly irreversible oxidation of the prosthetic heme group. ODQ has been used to study the role of cyclic guanosine monophosphate (cGMP) pathway in nitric oxide (NO) signal transduction.

Caution

Hygroscopic

Packaging

5, 25 mg in glass bottle

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability


All labs need water

Biomedical Applications
Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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