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O4000 Sigma

Oxythiamine chloride hydrochloride

≥95% (HPLC)

Synonym: 5-(2-Hydroxyethyl)-3-(4-hydroxy-2-methyl-5-pyrimidinylmethyl)-4-methylthiazolium chloride

  • CAS Number 614-05-1

  • Empirical Formula (Hill Notation) C12H16ClN3O2S · HCl

  • Molecular Weight 338.25

  •  MDL number MFCD00050656

  •  PubChem Substance ID 24897990

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Properties

Related Categories Biochemicals and Reagents, Vitamin B, Vitamin B1, Vitamins
InChI Key   QHUYPZVMEJLSEB-UHFFFAOYSA-N
assay   ≥95% (HPLC)
storage temp.   −20°C

Description

Biochem/physiol Actions

Oxythiamine inhibits Transketolase, the enzyme that controls the nonoxidative branch of the pentose phosphate pathway.

Oxythiamine (OT) is a thiamine antagonist that may be used as a transketolase inhibitor and to study anti-metastatic mechamisms, especially those involving metalloproteinases (MMP).

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
XJ7034100
Protocols & Articles

Articles

Nucleotide Synthesis in Cancer Cells

Neoplastic cells are highly dependent on the de novo synthesis of nucleotides to maintain sufficient pools to support DNA replication and the production of RNA. The metabolic pathways supporting nucl...
Keywords: Biofiles, Cancer, Catalysis, Citric Acid Cycle, DNA replication, Gene expression, Glycolysis, Metabolic Pathways, Metabolism, Metabolites, Nucleotide Synthesis, PAGE, Pentose phosphate pathway, Pyrimidine synthesis, Support

Peer-Reviewed Papers
15

References

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