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O6012 Sigma

Orexin A human, rat, mouse

≥97% (HPLC)

Synonym: Hypocretin 1

  • Empirical Formula (Hill Notation) C152H243N47O44S4

  • Molecular Weight 3561.10

  •  MDL number MFCD01635374

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Description

Amino Acid Sequence

Glp-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 [Disulfide Bridges: 6-12; 7-14]

Other Notes

Lyophilized from 0.1% TFA in H2O

Biochem/physiol Actions

Orexins (hypocretins) comprise a family of hypothalamic peptides that are involved in the initiation of sleep and in feeding behavior. Orexin A stimulates food intake through activation of the OX1 receptor. Orexin B activates OX2 receptors. Both OX1 and OX2 receptors are involved in maintaining arousal. OX2 receptors appear to be inhibitory autoreceptors on orexin-containing neurons.

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Safety Information

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Documents

Certificate of Analysis

Certificate of Origin

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