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O7262 Sigma

Anti-Osteoprotegerin antibody produced in goat

affinity isolated antibody

Synonym: Anti-OPG

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Description

Immunogen

recombinant human OPG expressed in the insect cell line Sf 21.

General description

The antibody will neutralize the biological activity of recombinant human OPG. The antibody shows 50% cross-reactivity with recombinant mouse OPG.

Physical form

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Biochem/physiol Actions

Osteoprotegerin (OPG) secreted by osteoblasts and osteogenis stromal stem cells belongs to the TNF receptor superfamily. OPG is expressed in bone marrow, osteoblasts, heart, lung, kidney, thymus, B lymphocytes, chondrocytes and smooth muscle cells. The ratio of OPG and receptor activator of NF-κB Ligand (RANKL) is crucial for determining the bone mass. Excess levels of OPG lead to osteopetrosis while deficiency results in osteoporosis.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
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Peer-Reviewed Papers
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