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O7262 Sigma

Anti-Osteoprotegerin antibody produced in goat

affinity isolated antibody

Synonym: Anti-OPG

Description

Immunogen

recombinant human OPG expressed in the insect cell line Sf 21.

General description

The antibody will neutralize the biological activity of recombinant human OPG. The antibody shows 50% cross-reactivity with recombinant mouse OPG.

Physical form

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Biochem/physiol Actions

Osteoprotegerin (OPG) secreted by osteoblasts and osteogenis stromal stem cells belongs to the TNF receptor superfamily. OPG is expressed in bone marrow, osteoblasts, heart, lung, kidney, thymus, B lymphocytes, chondrocytes and smooth muscle cells. The ratio of OPG and receptor activator of NF-κB Ligand (RANKL) is crucial for determining the bone mass. Excess levels of OPG lead to osteopetrosis while deficiency results in osteoporosis.

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