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O8137 Sigma

Osteoprotegerin/Fc Chimera from mouse

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym: OCIF, OPG

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Properties

Related Categories Bioactives/Supplements, Cell Biology, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones,
recombinant   expressed in NSO cells
InChI Key   XXUPLYBCNPLTIW-UHFFFAOYSA-N
assay   >95% (SDS-PAGE)
form   lyophilized powder
mol wt   calculated mol wt 70.9 kDa
  mol wt 100 kDa by SDS-PAGE (reducing)
impurities   endotoxin, tested
storage temp.   −20°C
Gene Information   mouse ... Tnfrsf11b(18383)

Description

Analysis Note

The biological activity is measured by its ability to neutralize apoptosis of mouse L-929 cells treated with 50 ng/ml recombinant human TRAIL.

General description

Mouse OPG (amino acids 22-401) is fused downstream of the human IL-3Rα signal sequence to the C-terminal histidine-tagged Fc portion of human IgG1.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Biochem/physiol Actions

OPG is a soluble secreted member of the tumor necrosis factor receptor superfamily that lacks any apparent cell-association motifs. It regulates the formation of osteoclasts and is involved in the regulation of bone resorption and remodeling. Human and mouse OPG share approximately 84% and 94% amino acid sequence identity, respectively, with rat OPG.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
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