O8139 Sigma

Opiorphin

≥98% (HPLC), lyophilized powder

  • CAS Number 864084-88-8

  • Empirical Formula (Hill Notation) C29H48N12O8

  • Molecular Weight 692.77

Properties

Related Categories Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Enkephalinase, Enzyme Inhibitors,
assay   ≥98% (HPLC)
form   lyophilized powder
storage condition   desiccated
  protect from light
color   white
solubility   H2O: soluble >1 mg/mL
storage temp.   −20°C

Description

Amino Acid Sequence

Gln-Arg-Phe-Ser-Arg

Biochem/physiol Actions

Opiorphin is a natural analgesic, secreted into human saliva. Opiorphin demonstrates dual-inhibitory potency on the enkephalin-inactivating ectopeptidases human NEP (hNEP) and human AP-N (hAP-N). As an analgesic, Opiorphin is six times stronger than the opiate morphine. Opiorphin is closely related to the rat sialorphin peptide, which is an inhibitor of pain perception and acts by potentiating endogenous micro- and δ-opioid receptor-dependent enkephalinergic pathways. In rat studies, Opiorphin suppressed pain sensation for both chemical-induced inflammation and acute physical pain. In both cases, the administered dose of 1 mg/kg provided the same painkilling power as 3-6 mg/kg of morphine.

Specifications

The peptide content is 78.9%

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