N-(3-Oxododecanoyl)-L-homoserine lactone

Papers

1. Acyl-homoserine lactone quorum sensing in gram-negative bacteria: a signaling mechanism involved in associations with higher organisms. Parsek, M.R., and Greenberg, E.P. Proc. Natl. Acad. Sci. U. S. A. 97, 8789-8793, (2000)

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2. Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1. Stoltz, D.A., et al. J. Clin. Invest. 118, 3123-3131, (2008)

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The interaction of N-acylhomoserine lactone quorum sensing signaling molecules with biological membranes: implications for inter-kingdom signaling. Davis BM, Jensen R, Williams P, O'Shea P. PLoS ONE 5, e13522, (2010)

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Immunomodulatory and Protective Roles of Quorum-Sensing Signaling Molecules N-Acyl Homoserine Lactones during Infection of Mice with Aeromonas hydrophila. Khajanchi BK, Kirtley ML, Brackman SM, Chopra AK. Infect. Immun. 79, 2646-2657, (2011)

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Defining the structure and function of acyl-homoserine lactone autoinducers. Churchill ME, Sibhatu HM, Uhlson CL. Methods Mol. Biol. 692, 159-171, (2011)

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High-performance liquid chromatography analysis of N-acyl homoserine lactone hydrolysis by paraoxonases. Teiber JF, Draganov DI. Methods Mol. Biol. 692, 291-298, (2011)

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Degradation of N-acylhomoserine lactone quorum sensing signaling molecules by potato root surface-associated chryseobacterium strains. Rashid R, Morohoshi T, Someya N, Ikeda T. Microbes Environ. 26, 144-148, (2011)

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Detection of acyl-homoserine lactones by Escherichia and Salmonella. Soares JA, Ahmer BM. Curr. Opin. Microbiol. 14, 188-193, (2011)

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Quorum sensing-dependent regulation and blockade of exoprotease production in Aeromonas hydrophila. Swift S, Lynch MJ, Fish L, et al. Infect. Immun. 67, 5192-5199, (1999)

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Role of quorum sensing in the pathogenicity of Burkholderia pseudomallei. Ulrich RL, Deshazer D, et al. J. Med. Microbiol. 53, 1053-1064, (2004)

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Quorum sensing in the genus Burkholderia. Eberl L. Int. J. Med. Microbiol. 296, 103-110, (2006)

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Synthesis of Pseudomonas quorum-sensing autoinducer analogs and structural entities required for induction of apoptosis in macrophages. Manabu Horikawa et al Bioorg. Med. Chem. Lett. 16, 2130-3, (2006)

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Modulation of gene expression via disruption of NF-KB signaling by a bacterial small molecule. Kravchenko, V.V. et al. Science 321, 259-263, (2008)

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Synthetic ligands that activate and inhibit a quorum-sensing regulator in Pseudomonas aeruginosa. Margrith E Mattmann et al Bioorg. Med. Chem. Lett. 18, 3072-5, (2008)

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Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators. Grant D Geske et al Bioorg. Med. Chem. Lett. 18, 5978-81, (2008)

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Microwave synthesis and evaluation of phenacylhomoserine lactones as anticancer compounds that minimally activate quorum sensing pathways in Pseudomonas aeruginosa. Colin M Oliver et al J. Med. Chem. 52, 1569-75, (2009)

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Medicinal chemistry as a conduit for the modulation of quorum sensing. Colin A Lowery et al J. Med. Chem. 53, 7467-89, (2010)

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Anti-Clostridium difficile potential of tetramic acid derivatives from Pseudomonas aeruginosa quorum-sensing autoinducers. Chihiro Ueda et al Antimicrob. Agents Chemother. 54, 683-8, (2010)

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Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone. Jadhav, G. P.; et al. J. Med. Chem. 54, 3348, (2011)

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Synthesis of 'clickable' acylhomoserine lactone quorum sensing probes: unanticipated effects on mammalian cell activation. Amanda L Garner et al Bioorg. Med. Chem. Lett. 21, 2702-5, (2011)

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Thiolactone modulators of quorum sensing revealed through library design and screening. Christine E McInnis et al Bioorg. Med. Chem. 19, 4820-8, (2011)

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Substituted lactam and cyclic azahemiacetals modulate Pseudomonas aeruginosa quorum sensing. Venkata L A Malladi et al Bioorg. Med. Chem. 19, 5500-6, (2011)

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