O9381 Sigma

Okadaic acid from Prorocentrum concavum

92-100% (HPLC)

DOWNLOAD MSDS (PDF)

Synonym: OA

Properties

Related Categories Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, O,
assay   92-100% (HPLC)
solubility   DMSO: ≥1 mg/mL
  ethanol: ≥1 mg/mL
  methanol: ≥1 mg/mL
  H2O: insoluble
shipped in   dry ice
storage temp.   −20°C

Description

Preparation Note

Isolated from unialgal cultures of dinoflagellates.

Biochem/physiol Actions

Dinoflagellate toxin and an ionophore-like polyether derivative of a 38 carbon, fatty acid. Readily enters cells. Inhibitor of type 1 and type 2A protein phosphatases. Does not inhibit tyrosine phosphatases, alkaline phosphatases or acid phosphatase. Known tumor promotor. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling.

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