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P0077 Sigma

Prostratin

≥98% (HPLC)

Synonym: 12-Deoxyphorbol-13-acetate, CCRIS 6292, NSC 623310

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology,
InChI Key   BOJKFRKNLSCGHY-HXGSDTCMSA-N
assay   ≥98% (HPLC)
form   white powder
solubility   DMSO: soluble10 mg/mL, clear
storage temp.   −20°C

Description

Packaging

1, 5 mg in glass bottle

Biochem/physiol Actions

Prostratin, an unusual non-tumorigenic phorbol ester, is an activator of protein kinase C (PKC) and also an activator of nuclear factor KB (NF-KB) mediated through activation of the IKKs (IKB kinases). Prostratin exhibits potent in vitro activity by inducing HIV expression in latently infected cell lines and primary cells, thus antagonizing HIV latency. Activation of PKC and NF-kB has been proposed as the mechanism of action. Prostratin also inhibits HIV entry into target cells by down-regulating CD4 and CXCR4 receptors.

Features and Benefits

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

PKC

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins. It was first identified in 1977 in bovine cerebellum by Nishizuka and co-workers as ...
Keywords: Apoptosis, Atomic absorption spectroscopy, Biological processes, Cancer, Catalysis, Cell signaling, Degradations, Diabetes, Gastrointestinal, Gene expression, Immobilization, Phosphorylations, Pulsed discharge ionization detector, Transcription, Ubiquitinations

Peer-Reviewed Papers
15

References

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