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P0103 Sigma

Prodigiosin hydrochloride

from Serratia marcescens, ≥98% (HPLC), powder

Synonym: 2,2′-Bi-1H-Pyrrole,4-methoxy-5-[(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl, 2-Methyl-3-amyl-6-methoxyprodigiosene hydrochloride

Properties

Related Categories Apoptosis Inducers, Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience
biological source   from Serratia marcescens
assay   ≥98% (HPLC)
form   powder
solubility   DMSO: soluble
  H2O: insoluble
  acetonitrile: soluble
  chloroform: soluble
  methanol: soluble
shipped in   wet ice
storage temp.   −20°C

Description

Biochem/physiol Actions

Prodigiosin, a tripyrrole red pigment biosynthesized by Serratia marcescens and other bacteria, exhibits antibacterial, anticancer, cytotoxic, immunosuppressive, and antiproliferative activities.1,2,3 Prodigiosin induces apoptosis in hematopoietic cancer cells and cells derived from other human cancers, including gastric and colon with no marked toxicity in nonmalignant cell lines.2,4,5 Morphological analysis of prodigiosin-treated cells demonstrated that prodigiosin induces cell shrinkage, chromatin condensation, reorganization of actin microfilament architecture, and detachment of cells from the cell culture substrate.6 Different targets and mechanisms of action are described for prodigiosin, including induction of single- and double-strand DNA breaks, modulation of pH, regulation of mitogen-activated protein kinase, and inhibition of cell cycle progression.5

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