Progesterone

Papers

Dynamic expression of calcium-regulatory molecules, TRPV6 and S100G, in the uterine endometrium during pregnancy in pigs. Choi, Y., et al. Biogerontology 81, 1122-30, (2009)

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Salivary Lipocalin Is Uniquely Expressed In The Uterine Endometrial Glands At The Time Of Conceptus Implantation And Induced By Interleukin 1beta In Pigs. Seo, H., et al. Biol. Reprod. 84, 279-87, (2011)

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Induced Lactation In Pubertal Heifers: Efficacy, Response To Bovine Somatotropin, And Profitability. Macrina, A.L., et al. J. Dairy Sci. 94, 1355-64, (2011)

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Ovarian hormones inhibit fat intake under binge-type conditions in ovariectomized rats. Zhiping Yu et al Physiol. Behav. 95, 501-7, (2009)

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Hormonal modulation of phonotaxis and advertisement-call preferences in the gray treefrog (Hyla versicolor). Noah M. Gordon et al Horm. Behav. 55, 121-7, (2009)

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Sexual experience changes sex hormones but not hypothalamic steroid hormone receptor expression in young and middle-aged male rats. Di Wu et al Horm. Behav. 56, 299-308, (2009)

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A balanced diet is necessary for proper entrainment signals of the mouse liver clock. Akiko Hirao et al PLoS ONE 4, e6909, (2009)

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Genetic analysis reveals an unexpected role of BMP7 in initiation of ureteric bud outgrowth in mouse embryos. Alexandre Gonçalves et al PLoS ONE 6, e19370, (2011)

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Replication efficiency of oncolytic vaccinia virus in cell cultures prognosticates the virulence and antitumor efficacy in mice. Nanhai G Chen et al J. Transl. Med. 9, 164, (2011)

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Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Giulia Caron et al J. Med. Chem. 48, 3269-79, (2005)

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Structure-based virtual screening for plant-based ERbeta-selective ligands as potential preventative therapy against age-related neurodegenerative diseases. Liqin Zhao et al J. Med. Chem. 48, 3463-6, (2005)

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Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening. Christian Laggner et al J. Med. Chem. 48, 4754-64, (2005)

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Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals. Markus A Lill et al J. Med. Chem. 48, 5666-74, (2005)

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Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability. Giorgio Ottaviani et al J. Med. Chem. 49, 3948-54, (2006)

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Docking and three-dimensional quantitative structure-activity relationship (3D QSAR) analyses of nonsteroidal progesterone receptor ligands. Annu A Söderholm et al J. Med. Chem. 49, 4261-8, (2006)

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In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. Giorgio Ottaviani et al J. Med. Chem. 50, 742-8, (2007)

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5-(3-Cyclopentyl-2-thioxo-2,3-dihydro-1H-benzimidazol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile: A novel, highly potent, selective, and orally active non-steroidal progesterone receptor agonist. Puwen Zhang et al Bioorg. Med. Chem. 15, 6556-64, (2007)

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Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bram Baert et al Bioorg. Med. Chem. 15, 6943-55, (2007)

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New functional assay of P-glycoprotein activity using Hoechst 33342. Henrik Müller et al Bioorg. Med. Chem. 15, 7470-9, (2007)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. Sean Ekins et al Drug Metab. Dispos. 35, 493-500, (2007)

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Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. Hiroyuki Sato et al J. Med. Chem. 51, 1831-41, (2008)

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An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin. Artem Cherkasov et al J. Med. Chem. 51, 2047-56, (2008)

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Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Jenny M Pedersen et al J. Med. Chem. 51, 3275-87, (2008)

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A tissue-selective nonsteroidal progesterone receptor modulator: 7,9-difluoro-5-(3-methylcyclohex-2-enyl)-2,2,4-trimethyl-1,2-dihydrochromeno[3,4-f]quinoline. Bijan Pedram et al J. Med. Chem. 51, 3696-9, (2008)

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Characterization of the drug binding specificity of rat liver fatty acid binding protein. Sara Chuang et al J. Med. Chem. 51, 3755-64, (2008)

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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Gustav Ahlin et al J. Med. Chem. 51, 5932-42, (2008)

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1,5-Dihydro-benzo[e][1,4]oxazepin-2(1H)-ones containing a 7-(5'-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators. Jeffrey C Kern et al Bioorg. Med. Chem. Lett. 18, 5015-7, (2008)

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Methoxylation of 3',4'-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells. Wang-Fun Fong et al Bioorg. Med. Chem. 16, 3694-703, (2008)

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Structure-activity relationships of new inhibitors of breast cancer resistance protein (ABCG2). Anne Pick et al Bioorg. Med. Chem. 16, 8224-36, (2008)

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Integrating high-content screening and ligand-target prediction to identify mechanism of action. Daniel W Young et al Nat. Chem. Biol. 4, 59-68, (2008)

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Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. José Marco-Contelles et al J. Med. Chem. 52, 2724-32, (2009)

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Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. Pelayo Camps et al J. Med. Chem. 52, 5365-79, (2009)

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Development and screening of water-soluble analogues of progesterone and allopregnanolone in models of brain injury. Christopher J MacNevin et al J. Med. Chem. 52, 6012-23, (2009)

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4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors. Thomas S Dexheimer et al J. Med. Chem. 52, 7122-31, (2009)

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Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. Mariana P Arce et al J. Med. Chem. 52, 7249-57, (2009)

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Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone. Edith Bellavance et al J. Med. Chem. 52, 7488-502, (2009)

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Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists. Scott K Thompson et al Bioorg. Med. Chem. Lett. 19, 4777-80, (2009)

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Search for MDR modulators: design, syntheses and evaluations of N-substituted acridones for interactions with p-glycoprotein and Mg2+. Palwinder Singh et al Bioorg. Med. Chem. 17, 2423-7, (2009)

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Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Lei Du-Cuny et al Bioorg. Med. Chem. 17, 6983-92, (2009)

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The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144. Deborah M Roll et al J. Nat. Prod. 72, 1944-8, (2009)

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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Jing Yuan et al Nat. Chem. Biol. 5, 765-71, (2009)

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Design, synthesis and evaluation of progesterone-adenine hybrids as bivalent inhibitors of P-glycoprotein-mediated multidrug efflux. Waël Zeinyeh et al Bioorg. Med. Chem. Lett. 20, 3165-8, (2010)

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Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. Pil H Lee et al Bioorg. Med. Chem. Lett. 20, 69-73, (2010)

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Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Francisco J Prado-Prado et al Bioorg. Med. Chem. 18, 2225-31, (2010)

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Targeting efflux pumps-In vitro investigations with acridone derivatives and identification of a lead molecule for MDR modulation. P. Singh, et al., Bioorg. Med. Chem. 18, 4212-4223, (2010)

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Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists. Yongli Du et al Bioorg. Med. Chem. 18, 4255-68, (2010)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Synthesis and modulation properties of imidazo[4,5-b]pyridin-7-one and indazole-4,7-dione derivatives towards the Cryptosporidium parvum CpABC3 transporter. Waël Zeinyeh et al Eur. J. Med. Chem. 45, 2480-8, (2010)

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Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. Nidhi Puri et al Eur. J. Med. Chem. 45, 4813-26, (2010)

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Neural computational prediction of oral drug absorption based on CODES 2D descriptors. A Guerra et al Eur. J. Med. Chem. 45, 930-40, (2010)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Combination of two pharmacophoric systems: synthesis and pharmacological evaluation of spirocyclic pyranopyrazoles with high ?? receptor affinity. Torsten Schläger et al J. Med. Chem. 54, 6704-13, (2011)

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Design and synthesis of tricyclic tetrahydroquinolines as a new series of nonsteroidal selective androgen receptor modulators (SARMs). Naoya Nagata et al Bioorg. Med. Chem. Lett. 21, 1744-7, (2011)

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Tetrahydroquinolines as a novel series of nonsteroidal selective androgen receptor modulators: structural requirements for better physicochemical and biological properties. Naoya Nagata et al Bioorg. Med. Chem. Lett. 21, 6310-3, (2011)

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Biological activity and ligand binding mode to the progesterone receptor of A-homo analogues of progesterone. Lautaro D Alvarez et al Bioorg. Med. Chem. 19, 1683-91, (2011)

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QSAR-based permeability model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 19, 2615-24, (2011)

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N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. Gema C González-Muñoz et al Eur. J. Med. Chem. 46, 2224-35, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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MAP kinases couple multiple functions of human progesterone receptors: degradation, transcriptional synergy, and nuclear association. Qiu, M., and Lange, C.A. J. Steroid Biochem. Mol. Biol. 85, 147-157, (2003)

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Progesterone receptors--animal models and cell signalling in breast cancer. Diverse activation pathways for the progesterone receptor: possible implications for breast biology and cancer. Lanari, C., and Molinolo, A.A. Breast Cancer Res. 4, 240-243, (2002)

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The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis. Anderson, E. Breast Cancer Res. 4, 197-201, (2002)

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Steroid hormone regulation of angiogenesis in the primate endometrium. Albrecht, E.D., and Pepe, G.J. Front. Biosci. 8, 416-429, (2003)

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Progesterone and the control of uterine cell proliferation and differentiation. Rider, V. Front. Biosci. 7, 1545-1555, (2002)

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Merck 14,7773

Beil. 7,IV,2395

Aldrich MSDS 1, 1539:B / Corp MSDS 1 (2), 2944:C / FT-IR 1 (2), 1052:B / FT-IR 2 (3), 4228:C / FT-NMR 1 (3), 578:A / IR-Spectra (3), 1496:F / RegBook 1 (2), 2859:O / Sax 6, 2290 / Sigma FT-IR 1 (1), 1316:A / Structure Index 1, 458:D:3