Calmodulin from bovine heart
lyophilized powder, 2,500-10,000 units/mg protein
DOWNLOAD MSDS (PDF)Synonym: Phosphodiesterase 3′:5′-cyclic nucleotide activator from bovine heart
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CAS Number 77107-46-1
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MDL number MFCD00131869
Properties
| Related Categories | Biochemicals and Reagents, Proteins and Derivatives, Redox More... |
| form | lyophilized powder |
| composition | Protein, ≥85% Lowry |
| storage temp. | −20°C |
| Gene Information | cow ... CALM3(520277) |
Description
Application
This is the protein activator required for the Ca2+ dependent activation of phosphodiesterase, 3′:5′-cyclic nucleotide, P0520.
Biochem/physiol Actions
Ca2+ binding protein that is required for activation of cyclic nucleotide-dependent phosphodiesterase. It is also a cofactor/activator of nitric oxide synthase, calcineurin, and many kinases including ATPase, myosin light chain kinase, and CAM kinase I, II, and III. It mediates ryanodine receptor activation by cyclic ADP ribose and is involved in intracellular Ca2+ homeostasis.
Preparation Note
Purified by a modification of the procedure of Teo, T.S., et al., J. Biol. Chem., 248, 588 (1973).
Unit Definition
One unit will stimulate 0.008 activated unit of phosphodiesterase, 3′:5′-cyclic nucleotide, P0520, in a 3 mL reaction volume at pH 7.5 and 30 °C, to 50% of the maximum activity of the enzyme when saturated with activator, in the presence of 0.01 mM Ca2+.
Physical form
Lyophilized powder containing buffer salts as imidazole and magnesium sulfate
Price and Availability
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