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P0615 Sigma

Proteinase 3 from human leukocytes

≥95% (PAGE)

Synonym: AGP7, Myeloblastin, P29B, PR-3, PR3 Ag

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Properties

Related Categories Biochemicals and Reagents, Enzymes, Inhibitors, and Substrates, Proteinase 3, Proteolytic Enzymes, Proteolytic Enzymes and Substrates,
assay   ≥95% (PAGE)
storage temp.   −20°C
Gene Information   human ... PRTN3(5657)

Description

General description

Proteinase 3 is found in high concentration in the primary granules of myeloid leukemia blasts.

Application

Proteinase 3 has been shown to be important in the pathogenesis of human emphysema. It has also been used in a study to investigate the liberation of the antibacterial and cytotoxic peptide LL-37 by cleavage of human cathelicidin hCAP-183.

Biochem/physiol Actions

Proteinase 3 (PR-3) is a serine protease expressed in the granules of neutrophils and monocytes. Also known as myeloblastin and p29b, it degrades elastin and is associated with myeloid leukemia and Wegener′s granulomatosis.

Used for the detection of anti-PR3 auto-antibodies in immunoassays.

Price and Availability


Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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