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P0741 Sigma

Introduction to Proteomics:Tools for the New Biology

  •  ISBN-10 0-89603-991-9

  •  ISBN-13 978-0-89603-991-9

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publication info   D.C. Liebler, ed., Humana Press, 2002, 201 pp., hard cover
mfr. no.   Humana

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This is an introduction to proteomics, a hot area in the biological sciences which enables scientists to study the protein complement of the genome. It refers to studying the functions of many proteins at one time, as opposed to how research was conducted in the mid-90′s where the technology did not enable the study of the entire protein system. From this, one is able to develop an overview of the way a genome functions and the role it plays in health and disease.

Table of Contents

I. Proteomics and the Proteome
1. Proteomics and the New Biology
2. The Proteome
II. Tools of Proteomics
3. Overview of Analytical Proteomics
4. Analytical Protein and Peptide Separations
5. Protein Digestion Techniques
6. Mass Spectrometers for Protein and Peptide Analysis
7. Protein Identification by Peptide Mass Fingerprinting
8. Peptide Sequence Analysis by Tandem Mass Spectrometry
9. Protein Identification with Tandem Mass Spectrometry
10. SALSA: An Algorithm for Mining Specific Features of Tandem MS Data
III. Applications of Proteomics
11. Mining Proteomes
12. Protein Expression Profiling
13. Identifying Protein-Protein Interactions and Protein Complexes
14. Mapping Protein Modifications
15. New Directions in Proteomics

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