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  • P0749 - Anti-Potassium Channel Kv11.1 Extracellular antibody produced in rabbit

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P0749 Sigma

Anti-Potassium Channel Kv11.1 Extracellular antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym: Anti-HERG, Anti-KCNH2

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Ion Channels, Antibodies to Potassium Channels,
species reactivity   human
application(s)   flow cytometry: 2-8 μg using live intact K562 (human chronic myelogenous leukemia) cells
  immunocytochemistry: 1:25
  western blot: 1:200 using HEK-KV11.1 transfected cells
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... KCNH2(3757)
mouse ... Kcnh2(16511)
rat ... Kcnh2(117018)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

peptide AFLLKETEEGPPATEC corresponding to residues 430-445 of human KV11.1. This sequence has 11/16 residues identical in mouse and rat and has 15/16 residues identical in rabbit and dog.

General description

The K+ channel family has been sub-grouped in to 2 TM, 4 TM and 6 TM K+ channels based on the number of transmembrane domains. The voltage-gated Potassium or Kv channels belong to the 6 TM K+ channel family that also include other sub-types such as the hERG, KCNQ, and EAG channels. Kv11.1 belongs to the EAG family and facilitates the repolarization of normal action potential in heart muscles. Genetic alterations in Kv11.1 can cause heart disorders such as long QT syndrome, sudden cardiac death and arhythmias. Kv11.1 also regulates cell growth and hence may be studied as a target for cancer treatment. Anti-Potassium channel Kv11.1 extracellular antibodies are specific to Kv11.1.

Physical form

Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.

Application

Anti-Potassium channel Kv11.1 extracellular antibodies may be used in immunofluorescence microscopy . It may also be used for the detection of Kv11.1 by techniques such as immunocytochemistry, flow cytometry using live intact K562 (human chronic myelogenous leukemia) cells and western blotting.

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