|Related Categories||Adrenergics, Adrenergics - Antagonists, Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules,|
|color||white to off-white|
|solubility||0.1 M NaOH: soluble0.2 mg/mL|
45% (w/v) aq 2-hydroxypropyl-β-cyclode|
|0.1 M HCl: soluble20 mg/mL|
|Gene Information||human ... ADRB1(153), HTR1A(3350)|
β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator.
Shelf-life of the powder is at least five years.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. P0778.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P261-P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xn|
|Risk Statements (Europe)||22-36/37/38|
|Safety Statements (Europe)||26-36|
Download BioFiles v7 n5 (3.18 Mb PDF) Back to Pharmaceutical Drugs and Drug Candidates homepage
BioFiles v7 n5, 2012, 5–20
Keywords: AGE, Antihypertensives, Cardiovascular, Clinical, Diuretics, Pharmaceutical, Reductions
β-Adrenoceptors are widely distributed, found at both central and peripheral sites, and are activated either via norepinephrine released from sympathetic terminals or via epinephrine (E4250, E4375) r...
Keywords: Antihypertensives, Atomic absorption spectroscopy, Diabetes, Gene expression, Neurotransmitters, Obesity, Reductions, Transduction
Pindolol suppresses serotonergic neuronal activity and does not block the inhibition of serotonergic neurons produced by 8-hydroxy-2-(di-n-propylamino) tetralin in awake cats. Fornal, C.A., et al. J. Pharmacol. Exp. Ther. 291, 229, (1999)
A Randomized Controlled Trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in the treatment of chronic tension-type facial pain. Agius AM, Jones NS, and Muscat R Rhinology 51(2), 143-53, (2013)
Both acute and subchronic treatments with pindolol, a 5-HT(1A) and β₁ and β₂ adrenoceptor antagonist, elevate regional serotonin synthesis in the rat brain: an autoradiographic study. Skelin I, Fikre-Merid M, and Diksic M Neurochem. Int. 61(8), 1417-23, (2012)
Fetal cardiac function after labetalol or pindolol for maternal hypertension in a sheep model of increased placental vascular resistance. Erkinaro T, Haapsamo M, Kavasmaa T, et al. Eur. J. Obstet. Gynecol. Reprod. Biol. 166(1), 18-22, (2013)
Simultaneous enantiomeric determination of propranolol, metoprolol, pindolol, and atenolol in natural waters by HPLC on new polysaccharide-based stationary phase using a highly selective molecularly imprinted polymer extraction. Morante-Zarcero S and Sierra I Chirality 24(10), 860-6, (2012)
Autoantibodies against cardiac β(1)-adrenoceptor do not affect the low-affinity state β(1)-adrenoceptor-mediated inotropy in rat cardiomyocytes. Abdelkrim MA, Mallem MY, Chatagnon G, et al. Can. J. Physiol. Pharmacol. 90(4), 407-14, (2012)
Can we really accelerate and enhance the selective serotonin reuptake inhibitor antidepressant effect? A randomized clinical trial and a meta-analysis of pindolol in nonresistant depression. Portella MJ, de Diego-Adeliño J, Ballesteros J, et al. J. Clin. Psychiatry 72(7), 962-9, (2011)
A short-term double-blind randomized controlled pilot trial with active or placebo pindolol in patients treated with venlafaxine for major depression. Martiny K, Lunde M, Bech P, et al. Nord. J. Psychiatry 66(3), 147-54, (2012)
Tachyphylaxis to the sumatriptan-induced contractile effect in the human uterine artery but not in human cerebral blood vessels: pharmacological demonstration of the 5-HT(1B) receptor functionality loss. Silva SA and Ribeiro CA Pharmacology 89(1-2), 29-36, (2012)
Simultaneous and sensitive capillary electrophoretic enantioseparation of three β-blockers with the combination of achiral ionic liquid and dual CD derivatives. Jin Y, Chen C, Meng L, et al. Talanta 89, 149-54, (2012)
Kinetic capillary electrophoresis with mass-spectrometry detection (KCE-MS) facilitates label-free solution-based kinetic analysis of protein-small molecule binding. Bao J, Krylova SM, Wilson DJ, et al. ChemBioChem. 12(17), 2551-4, (2011)
Serotonin-1A receptors in the dorsal periaqueductal gray matter mediate the panicolytic-like effect of pindolol and paroxetine combination in the elevated T-maze. Sela VR, Biesdorf C, Ramos DH, et al. Neurosci. Lett. 495(1), 63-6, (2011)
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. Michael H Abraham et al Eur. J. Med. Chem. 43, 478-85, (2008)
Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. Markus Fridén et al J. Med. Chem. 52, 6233-43, (2009)
Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human ?-adrenoceptors. Jillian G Baker et al J. Med. Chem. 54, 6874-87, (2011)
Corp MSDS 1 (2), 2840:C / FT-IR 2 (3), 3584:C / RegBook 1 (2), 2409:C / Sigma FT-IR 1 (1), 699:D / Structure Index 1, 382:B:3
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