|Related Categories||Adrenergics, Adrenergics - Antagonists, Antagonists, Approved Therapeutics/Drug Candidates, AstraZeneca,|
|solubility||ethanol: soluble10 mg/mL|
|DMSO: <14.5 mg/mL|
|H2O: soluble50 mg/mL (dissolve with heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.)|
45% (w/v) aq 2-hydroxypropyl-β-cyclode|
|Gene Information||human ... ADRB1(153), ADRB2(154), ADRB3(155), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358)|
β-adrenoceptor antagonist; 5-HT1/5-HT2 serotonin receptor antagonist; cardiac depressant (anti-arrhythmic).
Shelf-life of the solid is at least four years if stored protected from the uptake of moisture.
1 g in poly tube
5, 25, 100 g in poly bottle
Certificate of Analysis
Certificate of Origin
Download BioFiles v7 n5 (3.18 Mb PDF) Back to Pharmaceutical Drugs and Drug Candidates homepage
BioFiles v7 n5, 2012, 5–20
Keywords: AGE, Antihypertensives, Cardiovascular, Clinical, Diuretics, Pharmaceutical, Reductions
β-Adrenoceptors are widely distributed, found at both central and peripheral sites, and are activated either via norepinephrine released from sympathetic terminals or via epinephrine (E4250, E4375) r...
Keywords: Antihypertensives, Atomic absorption spectroscopy, Diabetes, Gene expression, Neurotransmitters, Obesity, Reductions, Transduction
Effects of cyclosporin on the pharmacokinetics of propranolol after intravenous and oral administration to control rats and to rats with uranyl nitrate-induced acute renal failure. Lee, Y.H. and Ku, Y.S. J. Pharm. Pharmacol. 51, 1149-1154, (1999)
Stereoselective blockade of central [3H]5-hydroxytryptamine binding to multiple sites (5-HT1A, 5-HT1B and 5-HT1C) by mianserin and propranolol. Alexander, B.S., and Wood, M.D. J. Pharm. Pharmacol. 39, 664-666, (1987)
Isoproterenol And CAMP Block ERK Phosphorylation And Enhance [Ca2+]i Increases And Oxygen Consumption By Muscarinic Receptor Stimulation In Rat Parotid And Submandibular Acinar Cells. Soltoff, S.P., and Hedden, L. J. Thorac. Cardiovasc. Surg. 285, 13337-48, (2010)
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A blinded, randomized, controlled trial of three doses of high-dose insulin in poison-induced cardiogenic shock. Cole JB, Stellpflug SJ, Ellsworth H, et al. Clin. Toxicol. (Phila.) 51(4), 201-7, (2013)
Comparative study of the molecularly imprinted polymers prepared by reversible addition-fragmentation chain transfer "bulk" polymerization and traditional radical "bulk" polymerization. Ma Y, Pan G, Zhang Y, et al. J. Mol. Recognit. 26(5), 240-51, (2013)
Dispersive liquid-liquid microextraction of propranolol enantiomers from human plasma based on the solidification of a floating organic droplet. Farhadi K, Hatami M, Forough M, et al. Bioanalysis 5(6), 701-10, (2013)
[Operational mechanism modification of bone mechanostat in an animal model of nutritional stress: effect of propranolol]. Pintos PM, Lezón CE, Bozzini C, et al. Rev. Invest. Clin. 65(1), 39-51, (2013)
Adenylyl cyclase anchoring by a kinase anchor protein AKAP5 (AKAP79/150) is important for postsynaptic β-adrenergic signaling. Zhang M, Patriarchi T, Stein IS, et al. J. Biol. Chem. 288(24), 17918-31, (2013)
A high-speed liquid chromatography/tandem mass spectrometry platform using multiplexed multiple-injection chromatography controlled by single software and its application in discovery ADME screening. Zhang J, Vath M, Ferraro C, et al. Rapid Commun. Mass Spectrom. 27(7), 731-7, (2013)
Effect of propranolol on hypertonic saline-evoked masseter muscle pain and autonomic response in healthy women during rest and mental arithmetic task. Bendixen KH, Terkelsen AJ, Baad-Hansen L, et al. J. Orofac. Pain 27(3), 243-55, (2013)
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