• USA Home
  • P105 - (±)-PPHT hydrochloride

EMAIL THIS PAGE TO A FRIEND
P105 Sigma

(±)-PPHT hydrochloride

≥98% (HPLC), solid

Synonym: (±)-2-(N-Phenethyl-N-propyl)amino-5-hydroxytetralin hydrochloride, N-0434

  • CAS Number 71787-90-1

  • Empirical Formula (Hill Notation) C21H27NO · HCl

  • Molecular Weight 345.91

  •  MDL number MFCD00055157

  •  PubChem Substance ID 24277925

Purchase

Properties

Related Categories Agonists, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Dopaminergics,
InChI Key   XWLCIDLCEZAOEY-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   solid
color   off-white
solubility   DMSO: ≥10 mg/mL
  H2O: ≥2 mg/mL
Gene Information   human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

Description

Biochem/physiol Actions

Potent D2 dopamine receptor agonist.

A series of new dopamine (DA) receptor agonists, of the 2-aminotetralin group, i.e. N-0434, N-0437 and N-0734 were investigated in both in vivo and in vitro pharmacological test systems. In vivo, the reversal of the gamma-butyrolactone-induced increase in rat central DOPA biosynthesis rate was taken as a measure of presynaptic activity. The homovanillic acid (HVA) decrease, after intraperitoneal and after oral administration of the drugs was also taken as a measure of presynaptic activity. Postsynaptic activity was measured in two behavioural models, i.e. reserpine reversal and stereotypy induction. The effects of (±)-PPHT (N-0434) these drugs on noradrenaline and dopamine turnover (alpha-MpT method) were studied in addition. The results indicate that all three compounds N-0434 ((±)-PPHT), N-0437 and N-0734 are potent and selective DA agonists that lack significant alpha 2 activity.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

Set your institution to view full text papers.
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?