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P1269 Sigma

Phorbol 12,13-dibutyrate

≥98% (TLC), powder

Synonym: PDBu

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cancer Research, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   BQJRUJTZSGYBEZ-YVQNUNKESA-N
assay   ≥98% (TLC)
form   powder
color   clear, light yellow, film
solubility   H2O: soluble30 μM
  DMSO: soluble
  acetone: soluble
  ethanol: soluble
storage temp.   −20°C
Gene Information   mouse ... Prkcd(18753)

Description

Biochem/physiol Actions

Tumor promoting phorbol ester that activates protein kinase C and promotes nitric oxide production.

Caution

Photosensitive

Features and Benefits

Less hydrophobic then PMA, making it easier to wash out of cells in tissue culture.

Packaging

1 mg in ampule

Reconstitution

Stock solution cannot be made in aqueous media; dissolve in a water-miscible organic solvent before dilution to working concentrations in aqueous media.

Price and Availability


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All labs need water
Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
EK7767000
Protocols & Articles

Articles

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
Vicki Caligur
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Biofiles, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Events, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Sequences, Transcription, Type, transformation

Peer-Reviewed Papers
15

References

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