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P1585 Sigma

PMA

for use in molecular biology applications

Synonym: 12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate, PMA, Phorbol 12-myristate 13-acetate, TPA

Properties

Related Categories Bioactive Small Molecules, Biochemicals, Cell Biology, Molecular Biology, Molecular Biology Reagents,
grade   for molecular biology
assay   ≥99% (TLC)
form   film
storage condition   protect from light
solubility   DMSO: soluble (DMSO solutions can be stored dark at −20 °C for at least six months.)
  ethanol: soluble
storage temp.   −20°C

Description

Frequently Asked Questions

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Biochem/physiol Actions

Potent tumor promoter; activates protein kinase C in vivo and in vitro.

Caution

Photosensitive, protect from light.

Application

Suitable for
• molecular biology studies as standard
• analytical studies of tumor promoters
• promotion of cell growth

General description

PMA (Phorbol 12-myristate 13-acetate) is an activator of protein kinase C (PKC) and a known tumor promoting agent. PMA also exhibits clastogenic (chromosome-breaking) activity.1

Price and Availability


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