P1585 Sigma

Phorbol 12-myristate 13-acetate

for molecular biology, ≥99% (TLC)

Synonym: 12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate, PMA, TPA

Properties

Related Categories Bioactive Small Molecules, Biochemicals, Cell Biology, Molecular Biology, Molecular Biology Reagents,
grade   for molecular biology
assay   ≥99% (TLC)
form   film
solubility   DMSO: soluble (DMSO solutions can be stored dark at −20 °C for at least six months.)
  ethanol: soluble
storage temp.   −20°C

Description

Frequently Asked Questions

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Biochem/physiol Actions

Potent tumor promoter; activates protein kinase C in vivo and in vitro.

Caution

Photosensitive

Application

Suitable for
• molecular biology studies as standard
• analytical studies of tumor promoters
• promotion of cell growth

General description

PMA (Phorbol 12-myristate 13-acetate) is an activator of protein kinase C (PKC) and a known tumor promoting agent. PMA also exhibits clastogenic (chromosome-breaking) activity.1

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



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