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P1639 Sigma

Patulin

≥98% (TLC)

Synonym: 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one

Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Biochemicals and Reagents
Quality Level   PREMIUM
assay   ≥98% (TLC)
storage temp.   −20°C

Description

Application

Patulin is a mycotoxin produced by a variety of molds, such as, Aspergillus and Penicillium. It is commonly found in apples. It is used as an inhibitor of potassium uptake and as an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase and to induce intra- and intermolecular protein crosslinking. It is used to study patulin contamination of bottled wine 1, DNA-damaging activity of patulin in Escherichia coli.2, and molecular cloning and functional characterization of two CYP619 cytochrome P450s involved in patulin biosynthesis3.

Biochem/physiol Actions

Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking. CYP619 cytochrome P450s are involved in biosynthesis of patulin in Aspergillus clavatus3.

Price and Availability

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Patulin solution

100 μg/mL in acetonitrile, analytical standard

Penicillic acid

≥98% (HPLC)

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