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P1645 Sigma

Palmitoyl-L-carnitine chloride

≥98% (TLC), powder

Synonym: O-Palmitoyl-L-carnitine chloride

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Properties

Related Categories Biochemicals and Reagents, Fatty Acyls, Fatty Esters, Fatty acyl carnitines, Lipids More...
InChI Key   GAMKNLFIHBMGQT-ZMBIFBSDSA-N
assay   ≥98% (TLC)
form   powder
color   white
solubility   H2O: soluble25 mg/mL (with heat or sonication)
storage temp.   −20°C

Description

Biochem/physiol Actions

Long-chain acylcarnitine and well-known intermediate in mitochondrial fatty acid oxidation. Modifies myocardial levels of high-energy phosphates and free fatty acids in the heart. Increases erythroid colony formation in culture. Reduces surface negative charge of erythrocytes and myocytes. Reported to affect currents and inhibit endothelium-dependent relaxation induced by acetylcholine and substance P in a dose-dependent manner by suppressing the intracellular calcium signal transduction in endothelial cells. Inhibits the Na/K pump current but has no effect on the intracellular calcium current in guinea pig ventricular cells. However, like oubain, it reversibly depolarizes the resting membrane, decreases action potential duration, and increases the amplitude of myocyte contractions.

Packaging

10, 25 mg in poly bottle

5 mg in glass bottle

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Characteristic Metabolites for Inborn Errors of Lipid Metabolism

Hereditary disorders in lipid metabolism include Tay-Sachs disease, Gaucher disease, Niemann-Pick disease, metachromatic leucodystrophy, Fabry disease, Refsum disease, and Tangier disease. These lipi...
Keywords: Degradations, Eliminations, Enzyme activity, Genetic, Lipid Metabolism, Metabolism, Metabolites, Vitamins

Mitochondrial Dysfunction and Metabolic Defects

Defects in mitochondrial function are associated with insulin resistance in both human and animal studies. Insulin resistance is associated with a decrease in the number, oxidative capacity, size, an...
Keywords: Acetylations, Apoptosis, Biofiles, Cancer, Carboxylations, Catalog, Catalysis, Citric Acid Cycle, Decarboxylations, Degradations, Diabetes, Enzyme-linked immunosorbent assay, Glycolysis, Immunofluorescence, Immunohistochemistry, Lipid Metabolism, Metabolism, Metabolites, Neurotransmitters, Obesity, Oxidations, Phosphorylations, Physiological Processes, Protocols, Transcription, Transduction, Transfection, Western blot

Peer-Reviewed Papers
15

References

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