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P186 Sigma

PD 123,319 di(trifluoroacetate) salt hydrate

powder, ≥98% (HPLC)

Synonym: S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid di(trifluoroacetate) salt hydrate

  • CAS Number 136676-91-0

  • Empirical Formula (Hill Notation) C31H32N4O3 · 2C2HF3O2 · xH2O

  • Molecular Weight 736.66 (anhydrous basis)

  •  MDL number MFCD11046022

  •  PubChem Substance ID 24898250

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Properties

Related Categories Angiotensin Receptor Antagonists, Angiotensins, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   PTSUEYBWHKDYBS-FPCIESGBSA-N
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
solubility   H2O: soluble10 mg/mL, clear
storage temp.   2-8°C

Description

Caution

Hygroscopic

Packaging

10 mg in poly bottle

Legal Information

Sold with permission of Warner-Lambert Company.

Application

PD123,319 di (trifluoroacetate) salt hydrate has been used in following experimental studies:
• To determine the effect of Angiotensin II (Ang II) on alveolar fluid clearance (AFC).
• To study the effect of PD123319 on AngII-induced abdominal aortic aneurysms (AAAs).
• To study its effect on Ang II-induced LRP1 overexpression and function in vascular smooth muscle cells (VSMCs) culture.

Biochem/physiol Actions

PD123,319 di (trifluoroacetate) salt hydrate is a widely used angiotensin II subtype-2 receptor (AT2R) antagonist to study the role of AT2 receptor in vitro and in vivo. It increases the AngII-induced abdominal aortic aneurysms (AAAs) without interacting with AT2 receptor.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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