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P2110 Sigma

Anti-Platelet-Derived Growth Factor Receptor α antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-PDGF Rα

Description

Immunogen

recombinant soluble human platelet-derived growth factor receptor α expressed in Sf 21 cells.

General description

Blocks cell surface human or mouse PDGF Receptor α mediated biological activity induced by PDGF-AA.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Biochem/physiol Actions

Platelet-derived growth factor (PDGF) is a serum growth factor purified from human platelets. The cellular effects of PDGF are mediated by binding to PDGF α- and PDGF β-receptors which leads to activation of downstream signaling via PI3K, STAT and Ras/MAPK. PDGFR stimulates the proliferation of cells of connective tissue and glial cells, survival, differentiation, chemotaxis and wound healing.

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