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P222 Sigma

Pandinotoxin-Kα

>99%, powder

  • CAS Number 185529-64-0

  • Empirical Formula (Hill Notation) C169H267N53O48S7

  • Molecular Weight 4033.71

  •  MDL number MFCD01324942

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Ion Channels, Monovalent Ion Channels, Potassium Channel Modulators,
assay   >99%
form   powder
color   off-white
storage temp.   −20°C

Description

Amino Acid Sequence

Thr-Ile-Ser-Cys-Thr-Asn-Pro-Lys-Gln-Cys-Tyr-Pro-His-Cys-Lys-Lys-αGlu-Thr-Gly-Tyr-Pro-Asn-Ala-Lys-Cys-Met-Asn-Arg-Lys-Cys-Lys-Cys-Phe-Gly-Arg

Legal Information

Sold with the permission of University of Maryland.

Biochem/physiol Actions

Pandinotoxin (PiTX) –Kα along with PiTX-Kβ and PiTXγ plays a vital role in blocking voltage-gated K+ channels.

General description

Pandinotoxin (PiTX)-Kα is a 35 amino acid peptide isolated from venom of the scorpion Pandinus imperaton. PiTX-Kβ and PiTXγ are other two members of pandinotoxin group. All the three pandinotoxins have structures similar to another scorpion toxin charybdotoxin (ChTX). The structure of PiTXs contains a β-sheet at the C- terminal end with three cysteines which is linked to the central α-helix by two disulfide bridges (C17-C35 and C13-C33) and to an extended amino-terminal fragment by the third disulfide bridge (C7-C28).

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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