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P2277 Sigma

Calmodulin from bovine brain

~95% (SDS-PAGE), lyophilized powder

Synonym: CaM, Phosphodiesterase 3′,5′-cyclic nucleotide activator from bovine brain

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Properties

assay   ~95% (SDS-PAGE)
form   lyophilized powder
activity   ~40,000 units/mg protein (Lowry)
mol wt   mol wt 16.8 kDa
impurities   salt, essentially free
storage temp.   −20°C
Gene Information   cow ... CALM3(520277)

Description

Biochem/physiol Actions

Ca2+ binding protein that is required for activation of cyclic nucleotide-dependent phosphodiesterase. It is also a cofactor/activator of nitric oxide synthase, calcineurin, and many kinases including ATPase, myosin light chain kinase, and CAM kinase I, II, and III. It mediates ryanodine receptor activation by cyclic ADP ribose and is involved in intracellular Ca2+ homeostasis.

Calmodulin is the Ca+2 dependent regulator protein (CDR), troponin C-like protein.

Unit Definition

One unit will stimulate 0.008 activated unit of phosphodiesterase, 3′:5′-cyclic nucleotide in a 3 ml reaction volume at pH 7.5 and 30 °C, to 50% of the maximum activity of the enzyme when saturated with activator, in the presence of 0.01 mM Ca2+.

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Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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