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P2284 Sigma

Plasminogen from rabbit plasma

lyophilized powder, 4-10 units/mg protein

Synonym: Profibrinolysin



Related Categories Application Index, Biochemicals and Reagents, Coagulation Proteins and Reagents, Enzymes, Inhibitors, and Substrates, Plasma & Blood Proteins,
form   lyophilized powder
composition   Protein, ~5% biuret
impurities   ε-aminocaproic acid, free
suitability   not suitable for streptokinase determination by clot formation procedure
foreign activity   plasmin <0.01 unit/unit plasminogen
storage temp.   2-8°C


Biochem/physiol Actions

Plasminogen is the inactive precursor of the protease plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration. Plasmin cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa. It activates matrix metalloproteinases by cleaving the inactive proenzymes. It is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β).


Prepare solution in buffer containing 20 mM lysine at neutral pH. The protein should be as concentrated as possible. Frozen in aliquots at −20 °C, it should be stable for several weeks.

Unit Definition

One unit will produce a ΔA275 of 1.0 from α-casein in 20 min at pH 7.5 at 37 °C, when measuring perchloric acid soluble products in a volume of 5.0 mL. Activity determined after activation to plasmin with urokinase.

Physical form

Contains NaCl, EDTA, lysine and Tris buffer

Price and Availability

Biomedical Applications
Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Protocols & Articles


Plasma Derived Proteins and Enzymes

Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Applications, Gas chromatography, Type

Peer-Reviewed Papers


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