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P2795 Sigma

Phytosphingosine hydrochloride Green Alternative

≥98%, from Saccharomyces cerevisiae

Synonym: 4-Hydroxysphinganine, D-Ribo-1,3,4-trihydroxy-2-aminooctadecane, D-Ribo-2-aminooctadecane-1,3,4-triol, PHS

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Complex Lipids, Glycolipids, Lipids,
biological source   from Saccharomyces cerevisiae
InChI Key   GDKAAHDFPOWGQE-RXQQAGQTSA-N
assay   ≥98%
greener alternative product characteristics   Less Hazardous Chemical Syntheses
Safer Solvents and Auxiliaries
Learn more about the Principles of Green Chemistry.
greener alternative category   Re-engineered
storage temp.   −20°C

Description

Biochem/physiol Actions

Phytosphingosine is a long chain sphingoid base that occurs broadly in yeast, plants and animals including mammals. In yeast it is involved in mediating the heat stress response, perhaps through activation of the AGC-type protein kinases, Pkh1, Pkh2, Ypk1, Ypk2, and Sch9. It is proapoptotic in human cancer cell lines. PHS induces ΔΨm and release of cytochrome c from mitochondria either directly or through activation of p38 MAPK pathway. This leads to activation of caspase 9 followed by activation of caspase 3 and programmed cell death.

Packaging

5, 25 mg in glass bottle

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
Protocols & Articles
Peer-Reviewed Papers
15

References

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Product #

Description

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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