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P3113 Sigma

Protein Kinase Functions

  •  ISBN-10 0-19-963770-9

  •  ISBN-13 978-0-19-963770-6



Related Categories Biochemistry Books, Books and Software, Labware, Proteomics Books
publication info   J. Woodgett, ed., Oxford University Press, 2000, 408 pp., hard cover
mfr. no.   Oxford University Press


General description

This provides a new focus on context and function of protein kinases, thus reflecting recent advances in kinase biology. Chapters on genetic approaches to protein kinase functions, MAP kinase pathway, and cyclin-dependent kinases are updated. Topics covered in depth are phosphatidylinositol 3-kinase signaling, JAK-STAT signaling, suppression of tyrosine kinases by the SOCS family proteins, TGFss superfamily, and involvement of protein kinases in response to DNA damage. Throughout, emphasis is placed not on individual kinases, but on functional aspects of the whole system and relationship between processes and molecules.

Table of Contents

Phosphatidylinositol 3-kinase signaling: a tale of two kinase activities
Mammalian MAP kinase pathways
Genetic approaches to protein kinase function in lower eukaryotes
Specificity in JAK-STAT signaling
On the road to destruction: suppression of protein tyrosine kinase
Cyclin-dependent protein kinases
Mechanisms and biology of signaling by serine/threonine kinase receptors form the TGFss superfamily
The ATM and DNA-PK proteins: The sensing, signaling and repair of DNA Damage

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