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P4170 Sigma

Propidium iodide

≥94.0% (HPLC)

Synonym: 3,8-Diamino-5-[3-(diethylmethylammonio)propyl]-6-phenylphenanthridinium diiodide

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Description

Application

Fluorescent stain for nucleic acids. Cell membrane integrity excludes propidium iodide from staining viable and apoptotic cells. Propidium iodide may be used in flow cytometry to evaluate cell viability when used with other dyes that stain viable cells or cells that are early in the apoptosis process.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Price and Availability

TruPAGE™ Pre-cast Polyacrylamide Gels


TruPAGE™ Pre-cast Polyacrylamide GelsTruPAGE Gels run true every time!

  • . 2-Year Shelf Life
  • . Superior Band Resolution
  • . Strong & Tear Resistant
  • . Higher Capacity Wells



DISCOVER Bioactive Small Molecules

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
Safety Statements (Europe) 
26-36/37
WGK Germany 
3
RTECS 
SF7949600

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Discover Bioactive Small Molecules for Apoptosis

Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Clinical, Diseases, Ligands, Neurodegenerative Diseases

Nancy-520 for DNA Detection and Quantitation

Nancy-520 is a fluorescent stain for double stranded DNA (dsDNA) on agarose electrophoresis gels, with higher sensitivity than ethidium bromide and an easy, fast, and robust staining procedure. It is...
Monika Baeumle
BioFiles 2009, 4.1, 4.
Keywords: Catalytic combustion detector, Electrophoresis

Peer-Reviewed Papers

References

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Multi-target-directed ligands to combat neurodegenerative diseases. Andrea Cavalli et al J. Med. Chem. 51, 347-72, (2008)

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Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease. Maria Laura Bolognesi et al J. Med. Chem. 50, 4882-97, (2007)

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Nitric oxide production by polymorphonuclear leucocytes in infected cystic fibrosis sputum consumes oxygen. Kolpen M, Bjarnsholt T, Moser C, et al. Clin. Exp. Immunol. 177(1), 310-9, (2014)

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Adult AIDS-like disease in a novel inducible human immunodeficiency virus type 1 Nef transgenic mouse model: CD4+ T-cell activation is Nef dependent and can occur in the absence of lymphophenia. Rahim MM J. Virol. 83(22), 11830-46, (2009)

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Piceatannol exhibits selective toxicity to multiple myeloma cells and influences the Wnt/ beta-catenin pathway. Schmeel FC, Schmeel LC, Kim Y, et al. Hematol. Oncol. 32(4), 197-204, (2014)

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Induction and flow cytometry identification of tetraploids from seed-derived explants through colchicine treatments in Catharanthus roseus (L.) G. Don. Xing SH J. Biomed. Biotechnol. 2011, 793198, (2011)

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Regulated expression of CCL21 in the prostate tumor microenvironment inhibits tumor growth and metastasis in an orthotopic model of prostate cancer. Nazita Yousefieh et al Cancer Microenviron. 2, 59-67, (2009)

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Application of a haematopoetic progenitor cell-targeted adeno-associated viral (AAV) vector established by selection of an AAV random peptide library on a leukaemia cell line. Stiefelhagen M, Sellner L, Kleinschmidt JA, et al. Genet. Vaccines Ther. 6, 12, (2008)

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The use of propidium iodide to assess excitotoxic neuronal death in primary mixed cortical cultures. Lau AC, Cui H, and Tymianski M Methods Mol. Biol. 399, 15-29, (2007)

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MAPK kinase kinase-1 is essential for cytokine-induced c-Jun NH2-terminal kinase and nuclear factor-kappaB activation in human pancreatic islet cells. Mokhtari D Diabetes 57(7), 1896-904, (2008)

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New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties. Rafael León et al Bioorg. Med. Chem. 16, 7759-69, (2008)

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Induction of mitochondrial biogenesis protects against caspase-dependent and caspase-independent apoptosis in L6 myoblasts. Dam AD, Mitchell AS, and Quadrilatero J Biochim. Biophys. Acta 1833(12), 3426-35, (2013)

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HMGB1 mediates endogenous TLR2 activation and brain tumor regression. Curtin JF PLoS Med. 6(1), e10, (2009)

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Magnetic nano-beads based separation combined with propidium monoazide treatment and multiplex PCR assay for simultaneous detection of viable Salmonella Typhimurium, Escherichia coli O157:H7 and Listeria monocytogenes in food products. Yang Y, Xu F, Xu H, et al. Food Microbiol. 34(2), 418-24, (2013)

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Propidium monoazide does not fully inhibit the detection of dead Campylobacter on broiler chicken carcasses by qPCR. Pacholewicz E, Swart A, Lipman LJ, et al. J. Microbiol. Methods 95(1), 32-8, (2013)

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Zebrafish miR-1 and miR-133 shape muscle gene expression and regulate sarcomeric actin organization. Mishima Y Genes Dev. 23(5), 619-32, (2009)

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Role of vitamin D receptor in the antiproliferative effects of calcitriol in tumor-derived endothelial cells and tumor angiogenesis in vivo. Ivy Chung et al Cancer Res. 69, 967-75, (2008)

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The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors. Kefas B J. Neurosci. 29(48), 15161-8, (2009)

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Bone marrow-derived cells from male donors do not contribute to the endometrial side population of the recipient. Cervelló I, Gil-Sanchis C, Mas A, et al. PLoS ONE 7(1), e30260, (2012)

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Involvement of cyclin B1 in progesterone-mediated cell growth inhibition, G2/M cell cycle arrest, and apoptosis in human endometrial cell. Tang L Reprod. Biol. Endocrinol. 7, 144, (2009)

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Nuclear entry of hyperbranched polylysine nanoparticles into cochlear cells. Weikai Zhang et al Int. J. Nanomedicine 6, 535-46, (2011)

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miR-34a regulates mouse neural stem cell differentiation. Márcia M. Aranha et al PLoS ONE 6, e21396, (2011)

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The shedding of CD62L (L-selectin) regulates the acquisition of lytic activity in human tumor reactive T lymphocytes. Yang S, Liu F, Wang QJ, et al. PLoS ONE 6(7), e22560, (2011)

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Reconstruction of endometrium from human endometrial side population cell lines. Cervelló I, Mas A, Gil-Sanchis C, et al. PLoS ONE 6(6), e21221, (2011)

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Centrosome/Cell cycle uncoupling and elimination in the endoreduplicating intestinal cells of C. elegans. Lu Y and Roy R PLoS ONE 9(10), e110958, (2014)

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Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis. Son G Hepatology 50(5), 1512-23, (2009)

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Novel DNA microarray system for analysis of nascent mRNAs. Masaya Ohtsu et al DNA Research 15, 241-51, (2008)

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Telomere targeting with a new G4 ligand enhances radiation-induced killing of human glioblastoma cells. Merle P, et al. Mol. Cancer Ther. 10(10), 1784-95, (2011)

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Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors. Stefania Butini et al J. Med. Chem. 51, 3154-70, (2008)

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Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2. Dai MS Mol. Cell. Biol. 28(13), 4365-76, (2008)

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EZH2 depletion blocks the proliferation of colon cancer cells. Fussbroich B, Wagener N, Macher-Goeppinger S, et al. PLoS ONE 6(7), e21651, (2011)

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Effect of 5-aminolevulinic acid-based photodynamic therapy via reactive oxygen species in human cholangiocarcinoma cells. Cy Hyun Kim et al Int. J. Nanomedicine 6, 1357-63, (2011)

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Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reaction. Doebis C Am. J. Pathol. 173(4), 1067-76, (2008)

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Endothelial progenitor cell number and colony-forming capacity in overweight and obese adults. MacEneaney OJ Int. J. Obes. 33(2), 219-25, (2009)

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Nerve growth factor and its receptor TrkA serve as potential markers for human corneal epithelial progenitor cells. Qi H Exp. Eye Res. 86(1), 34-40, (2008)

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The influence of scaffold microstructure on chondrogenic differentiation of mesenchymal stem cells. Zhang J, Wu Y, Thote T, et al. Biomed. Mater. 9(3), 035011, (2014)

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Anesthetic propofol reduces endotoxic inflammation by inhibiting reactive oxygen species-regulated Akt/IKKβ/NF-κB signaling. Chung-Hsi Hsing et al PLoS ONE 6, e17598, (2011)

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Selective induction of cell death in melanoma cell lines through targeting of Mcl-1 and A1. Senft D PLoS ONE 7(1), e30821, (2012)

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Synthesis, biological evaluation and molecular modeling of oxoisoaporphine and oxoaporphine derivatives as new dual inhibitors of acetylcholinesterase/butyrylcholinesterase. Huang Tang et al Eur. J. Med. Chem. 44, 2523-32, (2009)

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The rapid decrease in astrocyte-associated dystroglycan expression by focal cerebral ischemia is protease-dependent. Milner R J. Cereb. Blood Flow Metab. 28(4), 812-23, (2008)

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Multiple mechanisms mediate the taurine-induced proliferation of neural stem/progenitor cells from the subventricular zone of the adult mouse. Ramos-Mandujano G, Hernández-Benítez R, and Pasantes-Morales H Stem Cell Res. 12(3), 690-702, (2014)

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Detection of viable Escherichia coli O157:H7 in ground beef by propidium monoazide real-time PCR. Liu Y and Mustapha A Int. J. Food Microbiol. 170, 48-54, (2014)

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Chitin modulates innate immune responses of keratinocytes. Koller B, Müller-Wiefel AS, Rupec R, et al. PLoS ONE 6(2), e16594, (2011)

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Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells. Madhok BM Br. J. Cancer 102(12), 1746-52, (2010)

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A Genome-Wide Screen For β-Catenin Binding Sites Identifies A Downstream Enhancer Element That Controls C-Myc Gene Expression Yochum, G.S., et al. Mol. Cell. Biol. 28, 7368 - 7379, (2008)

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Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles. A. Samadi, et al Bioorg. Med. Chem. 18, 5861-5872, (2010)

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The depletion of nuclear glutathione impairs cell proliferation in 3t3 fibroblasts. Markovic J PLoS ONE 4(7), e6413, (2009)

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Hydrogen peroxide acts on sensitive mitochondrial proteins to induce death of a fungal pathogen revealed by proteomic analysis. Guozheng Qin et al PLoS ONE 6, e21945, (2011)

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Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway. Pais TF J. Neuroinflammation 5, 43, (2008)

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Porcine embryos produced after intracytoplasmic sperm injection using xenogeneic pig sperm from neonatal testis tissue grafted in mice. Honaramooz A Reprod. Fertil. Dev. 20(7), 802-7, (2008)

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Conservation and diversity of seed associated endophytes in Zea across boundaries of evolution, ethnography and ecology. Johnston-Monje D PLoS ONE 6(6), e20396, (2011)

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The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Ali S Cancer Res. 69(15), 6208-15, (2009)

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Involvement of enniatins-induced cytotoxicity in human HepG2 cells. Juan-García A, Manyes L, Ruiz MJ, et al. Toxicol. Lett. 218(2), 166-73, (2013)

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CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling. Strauss G J. Exp. Med. 206(6), 1379-93, (2009)

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Toxicological analysis of low-nicotine and nicotine-free cigarettes. Jinguo Chen et al Toxicology 249, 194-203, (2008)

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Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: implications for clinical translation. McMillin DW PLoS ONE 6(7), e20226, (2011)

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The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells. Chen MC, Chen CH, Wang JC, et al. Cell Death Dis. 4, e810, (2013)

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Retinoic acid-treated pluripotent stem cells undergoing neurogenesis present increased aneuploidy and micronuclei formation. Sartore, RC PLoS ONE 6(6), e20667, (2011)

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Functional high-throughput screening identifies the miR-15 microRNA family as cellular restriction factors for Salmonella infection. Maudet C, Mano M, Sunkavalli U, et al. Nat. Commun. 5, 4718, (2014)

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SOX2-RNAi attenuates S-phase entry and induces RhoA-dependent switch to protease-independent amoeboid migration in human glioma cells. Oppel F, Müller N, Schackert G, et al. Mol. Cancer 10, 137, (2011)

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Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity. Kvam, E PLoS ONE 4(5), e5727, (2009)

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Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments. Osorio KM, Lilja KC, and Tumbar T J. Cell Biol. 193(1), 235-50, (2011)

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Mitophagy switches cell death from apoptosis to necrosis in NSCLC cells treated with oncolytic measles virus. Xia M, Meng G, Jiang A, et al. Oncotarget 5(11), 3907-18, (2014)

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GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy. Heidari N Cell Death Dis. 1, e76, (2010)

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Perforin rapidly induces plasma membrane phospholipid flip-flop. Sunil S. Metkar et al PLoS ONE 6, e24286, (2011)

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Use of propidium monoazide and increased amplicon length reduce false-positive signals in quantitative PCR for bioburden analysis. Schnetzinger F, Pan Y, and Nocker A Appl. Microbiol. Biotechnol. 97(5), 2153-62, (2013)

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New aspects on the structure of neutrophil extracellular traps from chronic obstructive pulmonary disease and in vitro generation. Obermayer A, Stoiber W, Krautgartner WD, et al. PLoS ONE 9(5), e97784, (2014)

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Quantitative detection of viable Bifidobacterium bifidum BF-1 cells in human feces by using propidium monoazide and strain-specific primers. Fujimoto J and Watanabe K Appl. Environ. Microbiol. 79(7), 2182-8, (2013)

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Systemic and mucosal immune reactivity upon Mycobacterium avium ssp. paratuberculosis infection in mice. Koc A, Bargen I, Suwandi A, et al. PLoS ONE 9(4), e94624, (2014)

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Oroxylin A reverses P-glycoprotein-mediated multidrug resistance of MCF7/ADR cells by G2/M arrest. Zhu L, Zhao L, Wang H, et al. Toxicol. Lett. 219(2), 107-15, (2013)

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Sequencing of type I insulin-like growth factor receptor inhibition affects chemotherapy response in vitro and in vivo. Zeng X Clin. Cancer Res. 15(8), 2840-9, (2009)

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The detection of viable vegetative cells of Bacillus sporothermodurans using propidium monoazide with semi-nested PCR. Cattani F, Ferreira CA, and Oliveira SD Food Microbiol. 34(1), 196-201, (2013)

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New potent human acetylcholinesterase inhibitors in the tetracyclic triterpene series with inhibitory potency on amyloid ? aggregation. Julien Rouleau et al Eur. J. Med. Chem. 46, 2193-205, (2011)

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Development of PMA real-time PCR method to quantify viable cells of Pantoea agglomerans CPA-2, an antagonist to control the major postharvest diseases on oranges. Soto-Muñoz L, Teixidó N, Usall J, et al. Int. J. Food Microbiol. 180, 49-55, (2014)

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The nuclear accumulation of alpha-synuclein is mediated by importin alpha and promotes neurotoxicity by accelerating the cell cycle. Ma KL, Song LK, Yuan YH, et al. Neuropharmacology 82, 132-42, (2014)

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The death domain kinase RIP1 links the immunoregulatory CD40 receptor to apoptotic signaling in carcinomas. Knox PG, Davies CC, Ioannou M, et al. J. Cell Biol. 192(3), 391-9, (2011)

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Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. Huang Tang et al Bioorg. Med. Chem. Lett. 22, 2257-61, (2012)

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Effects of antithrombotic drugs fondaparinux and tinzaparin on in vitro proliferation and osteogenic and chondrogenic differentiation of bone-derived mesenchymal stem cells. Papathanasopoulos A J. Orthop. Res. 29(9), 1327-35, (2011)

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The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage. Tu HC Proc. Natl. Acad. Sci. U. S. A. 106(4), 1093-8, (2009)

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14-3-3sigma gene silencing during melanoma progression and its role in cell cycle control and cellular senescence. Schultz J Mol. Cancer 8, 53, (2009)

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Epstein-Barr virus-encoded microRNA BART15-3p promotes cell apoptosis partially by targeting BRUCE. Choi H, Lee H, Kim SR, et al. J. Virol. 87(14), 8135-44, (2013)

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Lapatinib induces autophagy, apoptosis and megakaryocytic differentiation in chronic myelogenous leukemia K562 cells. Huang HL, Chen YC, Huang YC, et al. PLoS ONE 6(12), e29014, (2011)

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Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus. Torsten Geissler et al Bioorg. Med. Chem. 18, 2173-7, (2010)

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Human DNA polymerase β polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity. Zhigang Guo et al Nucleic Acids Res. 37, 3431-41, (2009)

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Apoptotic cells induce dendritic cell-mediated suppression via interferon-γ-induced IDO. Charlotte A Williams et al Immunology 124, 89-101, (2008)

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A long noncoding RNA Sox2ot regulates lung cancer cell proliferation and is a prognostic indicator of poor survival. Hou Z, Zhao W, Zhou J, et al. Int. J. Biochem. Cell Biol. 53, 380-8, (2014)

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Discrimination of infectious hepatitis A viruses by propidium monoazide real-time RT-PCR. Sánchez G, Elizaquível P, and Aznar R Food Environ. Virol. 4(1), 21-5, (2012)

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Preparation and characterization of realgar nanoparticles and their inhibitory effect on rat glioma cells. An YL, Nie F, Wang ZY, et al. Int. J. Nanomedicine 6, 3187-94, (2011)

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Sequential transcription factor targeting for diffuse large B-cell lymphomas. Cerchietti LC Cancer Res. 68(9), 3361-9, (2008)

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Akt regulates centrosome migration and spindle orientation in the early Drosophila melanogaster embryo. Graham J. Buttrick et al J. Cell Biol. 180, 537-48, (2008)

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Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis. Menon MB, Sawada A, Chaturvedi A, et al. PLoS Genet. 10(8), e1004558, (2014)

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Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c. Ling Q, Xu X, Wei X, et al. J. Exp. Clin. Cancer Res 30, 66, (2011)

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Cell Density-dependent Inhibition Of Epidermal Growth Factor Receptor Signaling By P38alpha Mitogen-activated Protein Kinase Via Sprouty2 Downregulation. Swat, A., et al. Mol. Cell. Endocrinol. 29, 3332-43, (2009)

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Improving efficiency of viability-PCR for selective detection of live cells. Nkuipou-Kenfack E, Engel H, Fakih S, et al. J. Microbiol. Methods 93(1), 20-4, (2013)

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Benzofurans from Styrax agrestis as acetylcholinesterase inhibitors: structure-activity relationships and molecular modeling studies. Jiawei Liu et al J. Nat. Prod. 74, 2081-8, (2011)

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Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts. Gediya, L.K., et al. Bioorg. Med. Chem. 16, 3352-3360, (2008)

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HIV-1 and recombinant gp120 affect the survival and differentiation of human vessel wall-derived mesenchymal stem cells. Gibellini D Retrovirology 8, 40, (2011)

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Small compound 6-O-angeloylplenolin induces mitotic arrest and exhibits therapeutic potentials in multiple myeloma. Ying Liu et al PLoS ONE 6, e21930, (2011)

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Alkenyl group is responsible for the disruption of microtubule network formation in human colon cancer cell line HT-29 cells. Hosono T Carcinogenesis 29(7), 1400-6, (2008)

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The antidiabetic drug ciglitazone induces high grade bladder cancer cells apoptosis through the up-regulation of TRAIL. Plissonnier ML, Fauconnet S, Bittard H, et al. PLoS ONE 6(12), e28354, (2011)

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Aspergillus fumigatus RasA regulates asexual development and cell wall integrity. Fortwendel JR Eukaryotic Cell 7(9), 1530-9, (2008)

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Inhibition of Toxoplasma gondii growth by pyrrolidine dithiocarbamate is cell cycle specific and leads to population synchronization. Magnolia M. Conde de Felipe et al Mol. Biochem. Parasitol. 157, 22-31, (2008)

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Premature chromosome condensation induced by caffeine, 2-aminopurine, staurosporine and sodium metavanadate in S-phase arrested HeLa cells is associated with a decrease in Chk1 phosphorylation, formation of phospho-H2AX and minor cytoskeletal rearrangements. Rybaczek D Histochem. Cell Biol. 135(3), 263-80, (2011)

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DNA damage mediated s and g(2) checkpoints in human embryonal carcinoma cells. Wang X Stem Cells 27(3), 568-76, (2009)

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Pharmacological inhibition of PAR2 with the pepducin P2pal-18S protects mice against acute experimental biliary pancreatitis. Michael ES, Kuliopulos A, Covic L, et al. Am. J. Physiol. Gastrointest. Liver Physiol. 304(5), G516-26, (2013)

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BNP signaling is crucial for embryonic stem cell proliferation. Abdelalim EM PLoS ONE 4(4), e5341, (2009)

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Prostaglandin F2alpha promotes muscle cell survival and growth through upregulation of the inhibitor of apoptosis protein BRUCE. Jansen KM Cell Death Differ. 15(10), 1619-28, (2008)

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Role of adaptive and non-adaptive mechanisms forming complex patterns of genome size variation in six cytotypes of polyploid Allium oleraceum (Amaryllidaceae) on a continental scale. Duchoslav M, Šafářová L, and Jandová M Ann. Bot. 111(3), 419-31, (2013)

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Induction of eosinophil apoptosis by the cyclin-dependent kinase inhibitor AT7519 promotes the resolution of eosinophil-dominant allergic inflammation. Alessandri AL PLoS ONE 6(9), e25683, (2011)

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A novel in vitro sperm head decondensation protocol for rapid flow cytometric measurement of deoxyribonucleic acid content. Antonucci N, Manes S, Corradetti B, et al. Fertil. Steril. 99(7), 1857-61, (2013)

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Prediction of acetylcholinesterase inhibitors and characterization of correlative molecular descriptors by machine learning methods. Wei Lv et al Eur. J. Med. Chem. 45, 1167-72, (2010)

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Differential neuronal expression of receptor interacting protein 3 in rat retina: involvement in ischemic stress response. Huang JF, Shang L, Zhang MQ, et al. BMC Neurosci. 14, 16, (2013)

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Cytokine-dependent and cytokine-independent roles for Mcl-1: genetic evidence for multiple mechanisms by which Mcl-1 promotes survival in primary T lymphocytes. Dunkle A, Dzhagalov I, and He YW Cell Death Dis. 2, e214, (2011)

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Degenerate wave and capacitive coupling increase human MSC invasion and proliferation while reducing cytotoxicity in an in vitro wound healing model. Michelle Griffin et al PLoS ONE 6, e23404, (2011)

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Overexpression of UbcH10 alternates the cell cycle profile and accelerate the tumor proliferation in colon cancer. Fujita, T BMC Cancer 9, 87, (2009)

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Scutellaria barbate extract induces apoptosis of hepatoma H22 cells via the mitochondrial pathway involving caspase-3. Zhi-Jun Dai et al World J. Gastroenterol. 14, 7321-8, (2008)

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Neisseria gonorrhoeae infection protects human endocervical epithelial cells from apoptosis via expression of host antiapoptotic proteins. S. A. Follows et al Infect. Immun. 77, 3602-10, (2009)

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Loss of Tbx2 delays optic vesicle invagination leading to small optic cups. Behesti H Dev. Biol. 333(2), 360-72, (2009)

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Downregulation of heat shock protein 70 protects rheumatoid arthritis fibroblast-like synoviocytes from nitric oxide-induced apoptosis. Kang EH Arthritis. Res. Ther. 11(4), R130, (2009)

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A novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in human and mouse tissues, strongly inhibits cell growth in HeLa cells. Mishra, R.R., et al. PLoS ONE 6, e28433, (2011)

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Adeno-associated virus type 2 infection activates caspase dependent and independent apoptosis in multiple breast cancer lines but not in normal mammary epithelial cells. Samina Alam et al Mol. Cancer 10, 97, (2011)

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Plant geminivirus rep protein induces rereplication in fission yeast. Kittelmann K J. Virol. 83(13), 6769-78, (2009)

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Comparative analysis of oncogenic properties and nuclear factor-kappaB activity of latent membrane protein 1 natural variants from Hodgkin's lymphoma's Reed-Sternberg cells and normal B-lymphocytes. Nathalie Faumont et al Haematologica 94, 355-63, (2009)

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The UL15 protein of herpes simplex virus type 1 is necessary for the localization of the UL28 and UL33 proteins to viral DNA replication centres. Martin R. Higgs et al J. Gen. Virol. 89, 1709-15, (2008)

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Manipulating cell adhesions with optical tweezers for study of cell-to-cell interactions. Hu S, Gou X, Han H, et al. J. Biomed. Nanotechnol. 9(2), 281-5, (2013)

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Quantification of propidium iodide delivery using millisecond electric pulses: experiments. Sadik MM, Li J, Shan JW, et al. Biochim. Biophys. Acta 1828(4), 1322-8, (2013)

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Analysis of EGFR signaling pathway in nasopharyngeal carcinoma cells by quantitative phosphoproteomics. Ruan L Proteome Sci. 9, 35, (2011)

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Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c. Chen K J. Biomed. Sci. 18, 57, (2011)

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Detrimental role of CC chemokine receptor 4 in murine polymicrobial sepsis. Tobias Traeger et al Infect. Immun. 76, 5285-93, (2008)

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Induction of BAG2 protein during proteasome inhibitor-induced apoptosis in thyroid carcinoma cells. Wang HQ, Zhang HY, Hao FJ, et al. Br. J. Pharmacol. 155(5), 655-60, (2008)

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Turnover of BRCA1 involves in radiation-induced apoptosis. Weijun Liu et al PLoS ONE 5, e14484, (2010)

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Detection of viable but nonculturable Escherichia coli O157:H7 using propidium monoazide treatments and qPCR. Xiao XL, Tian C, Yu YG, et al. Can. J. Microbiol. 59(3), 157-63, (2013)

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ATG4B promotes colorectal cancer growth independent of autophagic flux. Liu PF, Leung CM, Chang YH, et al. Autophagy 10(8), 1454-65, (2014)

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Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells. Zhong W, Zhu H, Sheng F, et al. Autophagy 10(7), 1285-300, (2014)

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Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells, and synergizes with irinotecan. Maitra R, Seetharam R, Tesfa L, et al. Oncotarget 5(9), 2807-19, (2014)

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Small molecule screening reveals a transcription-independent pro-survival function of androgen receptor in castration-resistant prostate cancer. Natalia V. Narizhneva et al Cell Cycle 8, 4155-67, (2010)

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Inhibitory effect of IL-17 on neural stem cell proliferation and neural cell differentiation. Li Z, Li K, Zhu L, et al. BMC Immunol. 14, 20, (2013)

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Deletion of the protein kinase A regulatory subunit leads to deregulation of mitochondrial activation and nuclear duplication in Aspergillus fumigatus. Fuller KK Eukaryotic Cell 8(3), 271-7, (2009)

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Fibroblast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium. Chen PY, Qin L, Tellides G, et al. Sci. Signal. 7(344), ra90, (2014)

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Small molecule screening with laser cytometry can be used to identify pro-survival molecules in human embryonic stem cells. Sherman SP and Pyle AD PLoS ONE 8(1), e54948, (2013)

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Antibacterial activity and mechanism of action of ε-poly-L-lysine. Ye R, Xu H, Wan C, et al. Biochem. Biophys. Res. Commun. 439(1), 148-53, (2013)

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Gain in toxic function of stefin B EPM1 mutants aggregates: correlation between cell death, aggregate number/size and oxidative stress. Polajnar M, Zavašnik-Bergant T, Kopitar-Jerala N, et al. Biochim. Biophys. Acta 1843(9), 2089-99, (2014)

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Human dendritic cells infected with an adenoviral vector suppress proliferation of autologous and allogeneic T cells. Newton KR Immunology 125(4), 469-79, (2008)

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Quantification of viable Giardia cysts and Cryptosporidium oocysts in wastewater using propidium monoazide quantitative real-time PCR. Alonso JL, Amorós I, and Guy RA Parasitol. Res. 113(7), 2671-8, (2014)

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Constitutive expression of Bcl-2 in the haematopoietic compartment alters the metabolism of iron and increases resistance to mycobacterial infection. Flórido M Clin. Exp. Immunol. 156(1), 61-8, (2009)

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Expression of a novel peptide derived from PCNA damages DNA and reverses cisplatin resistance. Lingeman RG, Hickey RJ, and Malkas LH Cancer Chemother. Pharmacol. 74(5), 981-93, (2014)

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Molecular monitoring of Escherichia coli O157: H7 sterilization rate using qPCR and propidium monoazide treatment. Xing-Long X, Cong-Cong L, Yang Q, et al. Lett. Appl. Microbiol. 56(5), 333-9, (2013)

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Increased expression of AGS3 in rat brain cortex after traumatic brain injury. Wang W, Li Q, Zou F, et al. J. Neurosci. Res. 91(5), 726-36, (2013)

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Complementation for an essential ancillary non-structural protein function across parvovirus genera. Mihaylov IS, Cotmore SF, and Tattersall P Virology 468-470, 226-37, (2014)

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Moderate and severe malnutrition alters proliferation of spleen cells in rats. Cortés-Barberena E, Ceballos-Olvera I, González-Márquez H, et al. Cell Prolif. 46(2), 164-71, (2013)

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Combination of therapy with 5-fluorouracil and cisplatin with electroporation in human ovarian carcinoma model in vitro. Saczko J, Kamińska I, Kotulska M, et al. Biomed. Pharmacother. 68(5), 573-80, (2014)

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Structure-activity relationships and the cytotoxic effects of novel diterpenoid alkaloid derivatives against A549 human lung carcinoma cells. Koji Wada et al J. Nat. Med. 65, 43-9, (2010)

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Multiplex polymerase chain reaction using ethidium monoazide and propidium monoazide for distinguishing viable and dead cells of arcobacters in biofilm. Hrušková L, Mot'ková P, and Vytřasová J Can. J. Microbiol. 59(12), 797-802, (2013)

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Dual-color high-resolution fiber-FISH analysis on lethal white syndrome carriers in sheep. Pauciullo A, Fleck K, Lühken G, et al. Cytogenet. Genome Res. 140(1), 46-54, (2013)

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Islet preparation purity is overestimated, and less pure fractions have lower post-culture viability before clinical allotransplantation. Kitzmann JP, Karatzas T, Mueller KR, et al. Transplant. Proc. 46(6), 1953-5, (2014)

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Recombinant β-1,3-1,4-glucanase from Theobroma cacao impairs Moniliophthora perniciosa mycelial growth. Britto DS, Pirovani CP, Andrade BS, et al. Mol. Biol. Rep. 40(9), 5417-27, (2013)

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IAA-producing rhizobacteria from chickpea (Cicer arietinum L.) induce changes in root architecture and increase root biomass. Fierro-Coronado RA, Quiroz-Figueroa FR, García-Pérez LM, et al. Can. J. Microbiol. 60(10), 639-48, (2014)

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