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P4532 Sigma

(−)-N6-(2-Phenylisopropyl)adenosine

solid

Synonym: (R)-N6-(1-Methyl-2-phenylethyl)adenosine, N6-(L-2-Phenylisopropyl)adenosine, R-(−)-PIA

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Properties

Related Categories Adenosines/P2 Nucleotide Receptor - Agonists, Adenosines/P2 Nucleotide Receptors (Purinergics), Agonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
InChI Key   RIRGCFBBHQEQQH-SSFGXONLSA-N
form   solid
potency   1.17 nM Ki for A1 receptors (using [3H]CHA in rat forebrain preparations)
color   white
solubility   H2O: slightly soluble 0.3 mg/mL (Solutions may be stored for several days at 4°C.)
  45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.6 mg/mL (Solutions may be stored for several days at 4°C.)
storage temp.   2-8°C
Gene Information   human ... ADORA1(134)

Description

Packaging

25 mg in poly bottle

50, 100 mg in glass bottle

Biochem/physiol Actions

A1 adenosine receptor agonist. Affinity for adenosine receptor is approx. 100× that of the (+)-isomer.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

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