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P4553 Sigma

6-Phosphogluconic Dehydrogenase from yeast

lyophilized powder, ≥3.0 units/mg solid

Synonym: 6-Phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating), 6-Phosphogluconic Dehydrogenase from yeast

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Description

Packaging

25 units in glass bottle

Unit Definition

One unit will oxidize 1.0 μmole of 6-phospho-D-gluconate to D-ribulose 5-phosphate and CO2 per min at pH 7.4 at 37 °C in the presence of NADP+.

Application

6-phosphoglyconic dehydrogenase (6PGD) is a key enzyme in the oxidative portion of the hexose monophosphate shunt. It is specific for oxidized nicotinamide adenine dinucleotide phosphate (NADP+) . 6-phosphogluconate dehydrogenase is involved in the production of ribulose 5-phosphate, which is involved in nucleotide synthesis and the pentose phosphate pathway by generating NADPH. 6-phosphogluconate dehydrogenase is used to study nucleotide synthesis, glucose metabolism, and the protection of cells from oxidative damage

Biochem/physiol Actions

Enzyme activity is determined by measuring the reduction of NAD+ or NADP+. High levels of NADPH are believed to inhibit the enzyme, while 6-phosphogluconate acts to activate the enzyme.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Related Content

Enzymes & Proteins

Application Index | Enzyme Index | Substrate Index | Inhibitor Index | Cofactor Index | Lectin Index
Keywords: Cell signaling, Diagnostic, Drug discovery, Molecular biology

Peer-Reviewed Papers
15

References

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