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P4929 Sigma

Poly(deoxyinosinic-deoxycytidylic) acid sodium salt

double-stranded alternating copolymer

Synonym: Poly(dI-dC) • Poly(dI-dC) sodium salt

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Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Other Notes

Double-stranded alternating copolymer

Unit Definition

One unit will yield an A260 of 1.0 in 1.0 ml of 20 mM sodium phosphate/100 mM NaCl, pH 7.0 (1 cm light path)

Application

Poly(deoxyinosinic-deoxycytidylic) acid (Poly(dI-dC) • Poly(dI-dC)) is an alternating copolymer used as a DNA substrate for evaluation of DNA methytransfeases, such as DNA-methyltransferase 1 and as double-stranded DNA model for conformational studies of DNA structure dynamics and drug, small molecule, interactions.

Poly(deoxyinosinic-deoxycytidylic) acid sodium salt has been used in a study that synthesized and characterized bis(2-(pyrimidin-2-γl)ethoxy)alkanes and their pharmacological activity. Poly(deoxyinosinic-deoxycytidylic) acid sodium salt has also been used in a study that investigated the growth of calcium carbonate films on LB/LbL matrices.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
What is the molecular weight of Product P4929, Poly(deoxyinosinic-deoxycytidylic) acid sodium salt?
Molecular weight: Polymer size (by agarose gel electrophoresis) is lot dependent with a lower range of less than 150 to 550 base pairs and a high range of 3000 to over 5000 base pairs. Most of the material is between 1200 to 3000 base pairs.
How many milligrams of Product P4929, Poly(deoxyinosinic-deoxycytidylic) acid sodium salt, do I have?
The specifications for the product is approximately 13 U/mg, but the exact amount is lot specific.  One unit will yield an A260 of 1.0 in 1.0ml of water.  For example, the 5 unit size has approximately 0.384 mg.  The Specification Sheet may be accessed at the following link: http://www.sigmaaldrich.com/catalog/DataSheetPage.do?brandKey=SIGMA&symbol=P4929
Is Is Product P4929,  Poly(deoxyinosinic-deoxycytidylic) acid sodium salt (Poly(dI-dC), stable in solution?
Both the solution and solid are very stable and can be stored for extended periods (years) at -20 ºC.
What is the solubility of Is Product P4929,  Poly(deoxyinosinic-deoxycytidylic) acid sodium salt (Poly(dI-dC)?
This product is soluble in water or neutral buffer at 20 mg/ml.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
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Protocols & Articles
Peer-Reviewed Papers
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