|Related Categories||Antibacterial, Antibiotic powders, Antibiotics, Antibiotics A to Z, Antibiotics N-S,|
|potency||≥6,000 USP units per mg|
|solubility||H2O: soluble50 mg/mL|
|suitability||suitable for cell culture|
Recommended for use in cell culture applications at 50 mg/L. Used as a lipid A binding agent that induces pore formation in cell membranes and as immobilized (substrate bound) agent for removal of endotoxins.
Antibiotic with bactericidal action on E. coli.1,2 Binds to the lipid A portion of bacterial lipopolysaccharides.3 Induces pore formation in the membranes of cortex cells from excised sorghum roots.4
Mode of Action: Binds to and interferes with the permeability of the cytoplasmic membrane.
Antimicrobial spectrum: Gram-negative bacteria.
Mixture of Polymyxin B1 and B2 sulfate.
Stock solutions should be sterile filtered and stored at 2-8 °C. Stable at 37 °C for 5 days.
Certificate of Analysis
Certificate of Origin
1Application Key: CC = Callus Culture; PR = plant regeneration; EC = cotyledon, hypocotyl, or leaf disc culture; TS = transformant selection; SE = somatic embryogenesis; SSC = stem selection culture;...
Keywords: Antibiotics, Cell culture
4. Lerner, H.R., et al. Physiol. Plant. 57, 90, (1983)
Development of a selective enrichment broth supplemented with bacteriological charcoal and a high concentration of polymyxin B for the detection of Campylobacter jejuni and Campylobacter coli in chicken carcass rinses. Chon JW, Kim H, Yim JH, et al. Int. J. Food Microbiol. 162(3), 308-10, (2013)
The interaction of polysaccharide from Auricularia polytricha with quantum dots and the protection of plasmid DNA from damage. Wang W, Zhang G, and Zou J Appl. Biochem. Biotechnol. 169(8), 2263-72, (2013)
Intraventricular polymyxin B for the treatment of neonatal meningo-ventriculitis caused by multi-resistant Acinetobacter baumannii--case report and review of literature. Piparsania S, Rajput N, and Bhatambare G Turk. J. Pediatr. 54(5), 548-54, (2012)
Direct hemoperfusion with a polymyxin B column versus vasopressin for gram negative septic shock: a matched cohort study of the effect on survival. Sawa N, Ubara Y, Sumida K, et al. Clin. Nephrol. 79(6), 463-70, (2013)
Optimizing hollow-fiber-based pharmacokinetic assay via chemical stability study to account for inaccurate simulated drug clearance of rifampicin. New LS, Lim TP, Oh JW, et al. Anal. Bioanal. Chem 405(4), 1407-15, (2013)
Use of a surfactant (polysorbate 80) to improve MIC susceptibility testing results for polymyxin B and colistin. Sader HS, Rhomberg PR, Flamm RK, et al. Diagn. Microbiol. Infect. Dis. 74(4), 412-4, (2012)
A single-blinded randomized clinical trial comparing polymyxin B-trimethoprim and moxifloxacin for treatment of acute conjunctivitis in children. Williams L, Malhotra Y, Murante B, et al. J. Pediatr. 162(4), 857-61, (2013)
The novel polymyxin derivative NAB739 is remarkably less cytotoxic than polymyxin B and colistin to human kidney proximal tubular cells. Vaara M and Vaara T Int. J. Antimicrob. Agents 41(3), 292-3, (2013)
Cost-effectiveness of perioperative selective decontamination of the digestive tract versus placebo in elective gastrointestinal surgery. Dijksman LM, Roos D, Gerhards MF, et al. Dig. Surg. 29(5), 384-90, (2012)
10'(Z),13'(E)-heptadecadienylhydroquinone inhibits swarming and virulence factors and increases polymyxin B susceptibility in Proteus mirabilis. Liu MC, Lin SB, Chien HF, et al. PLoS ONE 7(9), e45563, (2012)
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