P4932 Sigma

Polymyxin B sulfate salt

powder, BioReagent, suitable for cell culture

Description

Application

Recommended for use in cell culture applications at 50 mg/L. Used as a lipid A binding agent that induces pore formation in cell membranes and as immobilized (substrate bound) agent for removal of endotoxins.

Biochem/physiol Actions

Antibiotic with bactericidal action on E. coli.1,2 Binds to the lipid A portion of bacterial lipopolysaccharides.3 Induces pore formation in the membranes of cortex cells from excised sorghum roots.4
Mode of Action: Binds to and interferes with the permeability of the cytoplasmic membrane.
Antimicrobial spectrum: Gram-negative bacteria.

Other Notes

Mixture of Polymyxin B1 and B2 sulfate.

Stock solutions should be sterile filtered and stored at 2-8 °C. Stable at 37 °C for 5 days.

Protocols & Applications

Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




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