P4932 Sigma

Polymyxin B sulfate salt

powder, BioReagent, suitable for cell culture



Recommended for use in cell culture applications at 50 mg/L. Used as a lipid A binding agent that induces pore formation in cell membranes and as immobilized (substrate bound) agent for removal of endotoxins.

Biochem/physiol Actions

Antibiotic with bactericidal action on E. coli.1,2 Binds to the lipid A portion of bacterial lipopolysaccharides.3 Induces pore formation in the membranes of cortex cells from excised sorghum roots.4
Mode of Action: Binds to and interferes with the permeability of the cytoplasmic membrane.
Antimicrobial spectrum: Gram-negative bacteria.

Other Notes

Mixture of Polymyxin B1 and B2 sulfate.

Stock solutions should be sterile filtered and stored at 2-8 °C. Stable at 37 °C for 5 days.

Protocols & Applications

Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Price and Availability

Suggested Laboratory Gloves

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