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P5015 Sigma

Protein Kinase Inhibitor from rabbit muscle

lyophilized powder, 0.2-1 inhibitor U/μg protein

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Description

Biochem/physiol Actions

Binds to the catalytic subunit of cyclic-AMP dependent protein kinase, displacing the regulatory subunit and inhibiting phosphorylating activity. The cAMP binding capacity of the regulatory subunit is enhanced. The amino acid sequence deduced from cDNA is 100% homologous with human PKI.

Packaging

Package size based on protein content.

Preparation Note

Fractionated essentially by procedure of Walsh, D.A., et al., J. Biol. Chem., 246, 1977 (1971), through TCA precipitation.

Quality

Crude

Unit Definition

One unit will transfer 1.0 picomole (10-12 mol) of phosphate from γ-32P-ATP to hydrolyzed and partially dephosphorylated casein (Product No. C 4765) per min at pH 6.5 at 30 °C.

Physical form

Lyophilized powder containing 5% potassium phosphate buffer salts

Price and Availability


Amplified Detection

Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
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