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P5280 Sigma

Sodium pyruvate

powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99%

Synonym: α-Ketopropionic acid sodium salt, 2-Oxopropanoic acid sodium salt, Pyruvic acid sodium salt

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Description

Biochem/physiol Actions

Sodium Pyruvate has shown antioxidant properties and protective effects against oxygen radicals. Pyruvate is produced as part of glycolysis and is an intermediate in many metabolic pathways. It can be converted into acetyl CoA and enter the TCA Cycle.

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Safety & Documentation

Safety Information

WGK Germany 
3

Protocols & Articles

Articles

Aerobic Glycolysis and the Warburg Effect

The Warburg effect is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer ce...
Keywords: Aerobic, Biofiles, Cancer, Cell proliferation, Clinical, Glycolysis, PAGE, Phosphorylations, Support, Transcription

Fatty Acid Synthesis and Metabolism in Cancer Cells

Proliferatively active cells require fatty acids for functions such as membrane generation, protein modification, and bioenergetic requirements. These fatty acids are derived either from dietary sour...
Keywords: Apoptosis, Biofiles, Cancer, Carboxylations, Catalysis, Citric Acid Cycle, Gene expression, Glycolysis, Metabolism, Oxidations, PAGE, Phosphorylations

Peer-Reviewed Papers

References

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Immune activation reduces sperm quality in the great tit. Sylvain Losdat et al PLoS ONE 6, e22221, (2011)

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Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice. Kim JD, Toda C, D'Agostino G, et al. Proc. Natl. Acad. Sci. U. S. A. 111(32), 11876-81, (2014)

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CXCL10 blockade protects mice from cyclophosphamide-induced cystitis. Senthilkumar K Sakthivel et al J. Immune Based Ther. Vaccines 6, 6, (2008)

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Carbonic anhydrase inhibitors. Inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with aliphatic and aromatic carboxylates. Alessio Innocenti et al Bioorg. Med. Chem. 17, 2654-7, (2009)

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RasGAP-derived fragment N increases the resistance of beta cells towards apoptosis in NOD mice and delays the progression from mild to overt diabetes. Bulat N PLoS ONE 6(7), e22609, (2011)

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Imaging single retrovirus entry through alternative receptor isoforms and intermediates of virus-endosome fusion. Jha NK PLoS Pathog. 7(1), e1001260, (2011)

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Differential Requirement for the CD45 Splicing Regulator hnRNPLL for Accumulation of NKT and Conventional T Cells. Mehmet Yabas et al PLoS ONE 6, e26440, (2011)

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Atmospheric-pressure plasma jet induces apoptosis involving mitochondria via generation of free radicals. Ahn HJ PLoS ONE 6(11), e28154, (2011)

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Cyclic AMP induces apoptosis in multiple myeloma cells and inhibits tumor development in a mouse myeloma model. Virginie Follin-Arbelet et al BMC Cancer 11, 301, (2011)

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Retinoic acid-treated pluripotent stem cells undergoing neurogenesis present increased aneuploidy and micronuclei formation. Sartore, RC PLoS ONE 6(6), e20667, (2011)

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Analysis of nitric oxide-dependent antimicrobial actions in macrophages and mice. Vazquez-Torres A Meth. Enzymol. 437, 521-38, (2008)

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Central carbon metabolism in the progression of mammary carcinoma. Adam D. Richardson et al Breast Cancer Res. Treat. 110, 297-307, (2007)

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Split-CreERT2: temporal control of DNA recombination mediated by split-Cre protein fragment complementation. Hirrlinger J PLoS ONE 4(12), e8354, (2009)

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Stress hormones collaborate to induce lymphocyte apoptosis after high level spinal cord injury. Lucin KM, Sanders VM, and Popovich PG J. Neurochem. 110(5), 1409-21, (2009)

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Role of the mitochondria in immune-mediated apoptotic death of the human pancreatic β cell line βLox5. Yaíma L. Lightfoot et al PLoS ONE 6, e20617, (2011)

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BNP signaling is crucial for embryonic stem cell proliferation. Abdelalim EM PLoS ONE 4(4), e5341, (2009)

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Differential protein expression following low temperature culture of suspension CHO-K1 cells. Niraj Kumar et al BMC Biotechnol. 8, 42, (2008)

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Characterization of clinical Enterococcus faecalis small-colony variants. Wellinghausen N J. Clin. Microbiol. 47(9), 2802-11, (2009)

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Identification of DNA regions and a set of transcriptional regulatory factors involved in transcriptional regulation of several human liver-enriched transcription factor genes. Miura H Nucleic Acids Res. 37(3), 778-92, (2009)

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Loss of runt-related transcription factor 3 expression leads hepatocellular carcinoma cells to escape apoptosis. Nakanishi Y BMC Cancer 11, 3, (2011)

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Aberrant anaplastic lymphoma kinase activity induces a p53 and Rb-dependent senescence-like arrest in the absence of detectable p53 stabilization. McDuff FK PLoS ONE 6(3), e17854, (2011)

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The ATP/DNA ratio is a better indicator of islet cell viability than the ADP/ATP ratio. T.M. Suszynski et al Transplant. Proc. 40, 346-50, (2009)

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Early and late pathogenic events of newborn mice encephalitis experimentally induced by itacaiunas and curionópolis bracorhabdoviruses infection. Diniz JA PLoS ONE 3(3), e1733, (2008)

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Beil. 3,IV,1505

FT-IR 1 (1), 550:D / FT-IR 2 (1), 891:C / FT-NMR 1 (1), 862:C / IR-Spectra (3), 328:C / IR-Spectra (2), 294:G / RegBook 1 (1), 635:K / Sigma FT-IR 1 (2), 876:C / Structure Index 1, 93:B:1

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P3662 Sodium pyruvate, Hybri-Max, powder, suitable for hybridoma

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