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P5296 Sigma

CTOP

≥97% (HPLC)

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Neuropeptides, Opioid Peptides, Other Opioid Peptides,
InChI Key   PZWWYAHWHHNCHO-FGHAYEPSSA-N
assay   ≥97% (HPLC)
storage temp.   −20°C
Gene Information   mouse ... Pnoc(18155)

Description

Amino Acid Sequence

Phe-Cys-Tyr-Trp-Orn-Thr-Pen-Thr-NH2 [Disulfide Bridge: 2-7]

Linkage

Somatostatin analog

Application

CTOP has been used:
• to study the anxiogenic effects induced by CTOP in mice and rat.
• to study the effect of μ-opioid antagonist, CTOP on the bovine milk-derived LF (BLF)-induced analgesia.
• to determine whether μ-opioid receptors act cooperatively with 5-hydroxytryptamine (5-HT1A) receptors to regulate the behaviors generated in the elevated T-maze (ETM).

Biochem/physiol Actions

D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) inhibits acute morphine-induced hypermotility and analgesic effect of morphine in a dose-dependent manner in vivo.

General description

D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) is a selective cyclic μ-opioid receptor antagonist.

Price and Availability


Amplified Detection

Making Headway

All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

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Description

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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