6-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine ≥98% (HPLC)

Properties

Related Categories	Adenosine Kinase; ATP:adenosine 5-prime-phosphotransferase (ADK), Aerobic Glycolysis (the Warburg Effect), BMPs and Receptors, Bioactive Small Molecules, Cancer Metabolism, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones, Inhibitors and Activators of the AMPK pathway, Inhibitors of Aerobic Glycolysis (the Warburg Effect), Kinase/Phosphatase Biology, P, Protein Kinase Inhibitors, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, Transforming Growth Factor-β (TGF-β) and Superfamily More...
assay	≥98% (HPLC)
form	powder
storage condition	protect from light
color	white to beige
solubility	DMSO: >2 mg/mL (warmed)
storage temp.	2-8°C

Description

Biochem/physiol Actions

Dorsomorphin is a selective inhibitor of Bone morphogenetic protein (BMP) signaling. It has been found to inhibit BMP signals required for embryogenesis and promoted significant neural differentiation from human pluripotent stem cell (hPSC) lines. Dorsomorphin also acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase); Ki = 109 nM in the presence of 5 μM ATP and the absence of AMP).

Price and Availability

Related Papers

Laminins, Via Heparan Sulfate Proteoglycans, Participate In Zebrafish Myotome Morphogenesis By Modulating The Pattern Of Bmp Responsiveness. Dolez, M., et al. Development 138, 97-106, (2011)

Documents

Certificate of Analysis

Safety Information

Symbol	GHS07
Signal word	Warning
Hazard statements	H302-H312-H332
Precautionary statements	P280
Personal Protective Equipment	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes (Europe)	Xn
Risk Statements (Europe)	20/21/22
Safety Statements (Europe)	36/37
WGK Germany	3

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Articles

Mitochondrial Dysfunction and Metabolic Defects

Defects in mitochondrial function are associated with insulin resistance in both human and animal studies. Insulin resistance is associated with a decrease in the number, oxidative capacity, size, an...
Keywords: Acetylations, Apoptosis, Cancer, Carboxylations, Catalysis, Citric Acid Cycle, Decarboxylations, Degradations, Diabetes, Enzyme-linked immunosorbent assay, Glycolysis, Immunofluorescence, Immunohistochemistry, Lipid Metabolism, Metabolism, Metabolites, Neurotransmitters, Obesity, Oxidations, Phosphorylations, Physiological Processes, Transcription, Transduction, Transfection, Western blot

Oncogenes and Tumor Suppressors Reprogram Metabolism

Proliferating cells require the biosynthesis of structural components for biomass production and for genomic replication. This requires a reprogramming of the metabolic pathways to ensure nutrients s...
Keywords: Aerobic, Antitumor agents, Apoptosis, Cancer, Degradations, Environmental, Gene expression, Glycolysis, Growth factors, Metabolic Pathways, Metabolism, Metabolites, Nucleotide Synthesis, PAGE, Pentose phosphate pathway, Phosphorylations