|Related Categories||Acetyl-CoA Carboxylase Inhibitors, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Metabolism, Cancer Research,|
|vapor pressure||10 mmHg ( 210 °C)|
|impurities||≤0.0005% Phosphorus (P)|
|≤0.1% Insoluble matter|
|bp||271.5 °C/100 mmHg(lit.)|
|solubility||chloroform: soluble0.5 M, clear, colorless|
|density||0.852 g/mL at 25 °C(lit.)|
|anion traces||chloride (Cl-): ≤0.05%|
|sulfate (SO42-): ≤0.05%|
|cation traces||Al: ≤0.005%|
|Gene Information||human ... FABP2(2169), FABP3(2170), FABP4(2167), FABP5(2171)|
Palmitic acid is a straight-chain 16-carbon fatty acid. Diets rich in palmitic acid, along with lauric and myristic acids, are associated with increased serum levels of low-density lipoprotein cholesterol. Palmitic acid is the first fatty acid produced by lipogenesis. It is a negative regulator of acetyl-CoA carboxylase (ACC) and is implicated in fatty acid-induced insulin resistance.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xi|
|Risk Statements (Europe)||36|
|Safety Statements (Europe)||26|
|Flash Point(F)||402.8 °F|
|Flash Point(C)||206 °C|
Proliferatively active cells require fatty acids for functions such as membrane generation, protein modification, and bioenergetic requirements. These fatty acids are derived either from dietary sour...
Keywords: Apoptosis, Cancer, Carboxylations, Catalysis, Gene expression, Glycolysis, Metabolism, Oxidations, PAGE, Phosphorylations
Obesity is a well-established risk factor for the development of insulin resistance. Obesity is associated with the increased deposition of lipids in non-adipose tissue with subsequent decreases in i...
Linda Stephenson, Ph.D.
Biofiles v6 n4, 9
Keywords: Angiogenesis, Antivirals, Apoptosis, Biological processes, Cardiovascular, Catalysis, Cell culture, Cell proliferation, Deposition, Diabetes, Gene expression, Growth factors, Hormones, Inflammation, Metabolism, Metabolites, Obesity, Phosphorylations, Physiological Processes, Reductions, Transcription, Transduction
[Changes in the content of plasma lipoproteins in persons subjected to diets prepared with sunflower oil alone or mixed with palm olein]. Giacopini de Z MI, Alonso HV, Sánchez J, et al. Invest. Clin. 54(2), 171-9, (2013)
Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity. Malmgren S, Spégel P, Danielsson AP, et al. J. Biol. Chem. 288(17), 11973-87, (2013)
Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood. Kien CL, Bunn JY, Tompkins CL, et al. Am. J. Clin. Nutr. 97(4), 689-97, (2013)
Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43. Kong E, Peng S, Chandra G, et al. J. Biol. Chem. 288(13), 9112-25, (2013)
Study on analysis of waste edible oil with deterioration and removal of acid value, carbonyl value, and free fatty acid by a food additive (calcium silicate). Ogata F, Tanaka Y, Tominaga H, et al. J. Oleo Sci. 62(2), 109-14, (2013)
Palmitate induces apoptosis in mouse aortic endothelial cells and endothelial dysfunction in mice fed high-calorie and high-cholesterol diets. Lu Y, Qian L, Zhang Q, et al. Life Sci. 92(24-26), 1165-73, (2013)
A novel mechanism by which SDF-1β protects cardiac cells from palmitate-induced endoplasmic reticulum stress and apoptosis via CXCR7 and AMPK/p38 MAPK-mediated interleukin-6 generation. Zhao Y, Tan Y, Xi S, et al. Diabetes 62(7), 2545-58, (2013)
Post-modification of preformed liposomes with novel non-phospholipid poly(ethylene glycol)-conjugated hexadecylcarbamoylmethyl hexadecanoic acid for enhanced circulation persistence in vivo. Nag OK, Yadav VR, Hedrick A, et al. Int. J. Pharm. 446(1-2), 119-29, (2013)
Kainate receptor post-translational modifications differentially regulate association with 4.1N to control activity-dependent receptor endocytosis. Copits BA and Swanson GT J. Biol. Chem. 288(13), 8952-65, (2013)
Hydrogen peroxide production regulates the mitochondrial function in insulin resistant muscle cells: effect of catalase overexpression. Barbosa MR, Sampaio IH, Teodoro BG, et al. Biochim. Biophys. Acta 1832(10), 1591-604, (2013)
Highly sensitive detection of pathogen Escherichia coli O157:H7 by electrochemical impedance spectroscopy. Barreiros dos Santos M, Agusil JP, Prieto-Simón B, et al. Biosens. Bioelectron. 45, 174-80, (2013)
Eicosapentaenoic acid suppresses palmitate-induced cytokine production by modulating long-chain acyl-CoA synthetase 1 expression in human THP-1 macrophages. Nakakuki M, Kawano H, Notsu T, et al. Atherosclerosis 227(2), 289-96, (2013)
Quantitative analysis for organic acids in biological samples: batch isolation followed by gas chromatographic-mass spectrometric analysis. Hoffmann G, Aramaki S, Blum-Hoffmann E, et al. Clin. Chem. 35(4), 587-95, (1989)
Effect of alpha-1-acid glycoprotein, albumin and palmitic acid on the brain and salivary gland extraction of warfarin in rats. Urien S, Morin D, and Tillement JP J. Pharmacol. Exp. Ther. 248(2), 781-5, (1989)
Insulin sensitivity is related to the fatty acid composition of serum lipids and skeletal muscle phospholipids in 70-year-old men. Vessby B, Tengblad S, and Lithell H Diabetologia 37(10), 1044-50, (1994)
Modulation of the activity of the human cholesteryl ester transfer protein by carboxylated derivatives. Evidence for 13-cis-retinoic acid as a potent activator of the protein's activity in plasma. Florentin E, Athias A, and Lagrost L Eur. J. Biochem. 240(3), 699-706, (1996)
A method for quantitative acylcarnitine profiling in human skin fibroblasts using unlabelled palmitic acid: diagnosis of fatty acid oxidation disorders and differentiation between biochemical phenotypes of MCAD deficiency. Okun JG, Kölker S, Schulze A, et al. Biochim. Biophys. Acta 1584(2-3), 91-8, (2002)
Oral absorption of insulin encapsulated in artificial chyles of bile salts, palmitic acid and alpha-tocopherol dispersions. Mesiha MS, Ponnapula S, and Plakogiannis F Int. J. Pharm. 249(1-2), 1-5, (2002)
Bile and unsaturated fatty acids inhibit the binding of cholera toxin and Escherichia coli heat-labile enterotoxin to GM1 receptor. Arpita Chatterjee et al Antimicrob. Agents Chemother. 52, 220-4, (2008)
Aldrich MSDS 1, 1419:D / Arctander, 2447 / Corp MSDS 1 (2), 2676:C / FT-IR 2 (1), 760:A / FT-IR 1 (1), 485:A / FT-NMR 1 (1), 756:B / IR-Spectra (2), 258:A / IR-Spectra (3), 286:A / NMR-Reference 2 (1), 422:D / RegBook 1 (1), 535:J / RegBook 47 (1), 535:J / Sax 6, 2113 / Sigma FT-IR 1 (1), 1448:A / Structure Index 1, 75:D:6 / Vapor Phase 3, 577:B
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