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P5976 Sigma

Anti-Platelet-Derived Growth Factor-BB antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-PDGF-BB

Description

Immunogen

Recombinant human PDGF-BB expressed in Escherichia coli.

General description

Platelet-Derived Growth Factor-BB (PDGF-BB) is a cystine-linked homodimer that belongs to PDGF growth factor family and is expressed mainly by vascular endothelium, megakaryocytes and Leydig cells. It has key roles in regulating neurogenesis, producing proinflammatory cytokines by orbital fibroblasts in Graves′ Ophthalmopathy, cell proliferation, development, angiogenesis and cell survival. Anti-Platelet-Derived Growth Factor-BB antibody can be used for neutralizing the biological activity of recombinant human PDGF-BB, recombinant human-AB, natural human PDGF, rat PDGF-BB, and porcine PDGF-BB. It can also neutralize recombinant human PDGF-AA at 50-100 fold high IgG concentration. Goat Anti-Platelet-Derived Growth Factor-BB antibody reacts specifically with human PDGF-BB. The product has also shown less than 10% cross-reactivity for recombinant human PDGF-AA.

Physical form

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline pH 7.4 with 5% trehalose.

Application

Anti-Platelet-Derived Growth Factor-BB antibody can be used in immunoblotting and ELISA.

Price and Availability


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