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P6149 Sigma

Progesterone

γ-irradiated, BioXtra, suitable for cell culture

Synonym: 4-Pregnene-3,20-dione

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Properties

Related Categories Bioactives and Supplements for Stem Cell Expansion, Bioactives/Supplements, Cell Biology, Cell Culture, Cell Signaling and Neuroscience,
description   synthesized from materials derived from plant source
InChI Key   RJKFOVLPORLFTN-LEKSSAKUSA-N
sterility   γ-irradiated
product line   BioXtra
assay   ≥99%
form   powder
potency   0.1-20 ng/mL
mp   128-132 °C(lit.)
suitability   suitable for cell culture
Gene Information   human ... ABCB1(5243), AR(367), CYP2C9(1559), EBP(10682), ESR1(2099), ESR2(2100), NR3C1(2908), NR3C2(4306), PGR(5241), SERPINA6(866)
mouse ... Esr1(13982)
rat ... Ar(24208), Nr3c1(24413), Pgr(25154)

Description

Application

Use in cell culture applications to study sterol regulation of cell signaling and gene expression.

Other Notes

Steroid hormone produced by the corpus luteum.

Reconstitution

To prepare 20 μg/ml stock solution, add 1 ml absolute ethanol, gently swirl to dissolve, add 49 ml sterile medium.

Physical form

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Biochem/physiol Actions

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

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Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
TW0175000
Protocols & Articles
Peer-Reviewed Papers
15

References

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