• USA Home
  • P6188 - Prostaglandin I2 sodium salt

EMAIL THIS PAGE TO A FRIEND
P6188 Sigma

Prostaglandin I2 sodium salt

≥96% (HPLC), synthetic, powder

Synonym: (5Z,9α,11α,13E,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid sodium salt, Epoprostenol sodium salt, PGI2-Na, Prostacyclin sodium salt

Purchase

Properties

Related Categories Arachidonic Acid Cascade, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Eicosanoids (Prostaglandins, Leukotrienes),
biological source   synthetic
InChI Key   OURCVRVJQMLUNA-QFDVFERUSA-M
assay   ≥96% (HPLC)
form   powder
color   white to off-white
solubility   H2O: soluble1 mg/mL (Hydrolyzes to 6-ketoprostaglandin F in aqueous solution.)
  ethanol: soluble50 mg/mL
storage temp.   −20°C

Description

Packaging

1, 5, 10 mg in glass bottle

Biochem/physiol Actions

Prostacyclin is a short-lived product of the cyclooxygenase pathway in vascular endothelial cells. It is a potent inhibitor of platelet aggregation by antagonizing thromboxane A2 and stimulating platelet adenylyl cyclase. Nitric oxide is also produced in vascular endothelium where it inhibits platelet aggregation, regulates inducible cyclooxygenase production, and may work synergistically with prostacyclin to attenuate the thrombotic process. Prostacyclin is vasoprotective, protecting arterial walls from injury-induced lesions and cytoprotective in the liver and gastrointestinal tract.

Prostacyclin therapy improves hemodynamics in pulmonary arterial hypertension.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




All labs need water
Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Anticoagulants

Download BioFiles v7 n5 (3.18 Mb PDF) Back to Pharmaceutical Drugs and Drug Candidates homepage
Sami Barghshoon
BioFiles v7 n5, 2012, 25–26
Keywords: Anticoagulants, Cardiovascular, Pharmaceutical

Peer-Reviewed Papers
15

References

Set your institution to view full text papers.
Related Products

related product

Product #

Description

Add to Cart

92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?